Sridar Narayanan - profile revision

Technical support Web support
1

My overall research interest is to study mechanisms of injury, repair and progression in neurological diseases, particularly multiple sclerosis (MS), through the development and in vivo application of advanced brain image acquisition and analysis techniques. Current projects include: development and validation of a method to detect subpial cortical demyelinating lesions in living MS patients using surface-based analysis of structural magnetic resonance imaging (MRI) and myelin-sensitive magnetization transfer imaging (MTI); development of in vivo markers of demyelination and remyelination in new lesions based on MTI, and refinement of this technique to provide a robust biomarker for use in clinical trials of new therapies designed to promote remyelination in MS; studying the extent and importance of blood-brain barrier disruption in MS, both focal and diffuse, using dynamic contrast-enhanced MRI; studying acquired demyelination syndromes and MS in children. All of this work is intensely collaborative, involving physicists, engineers, neurologists, immunologists, neuropsychologists and other people with specialized skills. Our group has fostered excellent collaborative links both within the MNI and beyond.

Selected Publications

    • Akbar, N., Till, C., Sled, J. G., Binns, M. A., Doesburg, S. M., Aubert-Broche, B., . . . Banwell, B. (2016). Altered resting-state functional connectivity in cognitively preserved pediatric-onset MS patients and relationship to structural damage and cognitive performance. Multiple Sclerosis (Houndmills, Basingstoke, England), 22(6), 792-800. 10.1177/1352458515602336 Link to item
    • Arnold, D. L., Narayanan, S., & Antel, S. (2013). Neuroprotection with glatiramer acetate: Evidence from the PreCISe trial. Journal of Neurology, 260(7), 1901-1906. 10.1007/s00415-013-6903-5 Link to item
    • Aubert-Broche, B., Fonov, V., Narayanan, S., Arnold, D. L., Araujo, D., Fetco, D., . . . Canadian Pediatric Demyelinating Disease Network. (2014). Onset of multiple sclerosis before adulthood leads to failure of age-expected brain growth. Neurology, 83(23), 2140-2146. 10.1212/WNL.0000000000001045 Link to item
    • Aubert-Broche, B., Weier, K., Longoni, G., Fonov, V. S., Bar-Or, A., Marrie, R. A., . . . Canadian Pediatric Demyelinating Disease Network. (2017). Monophasic demyelination reduces brain growth in children. Neurology, 88(18), 1744-1750. 10.1212/WNL.0000000000003884 Link to item
    • Badhwar, A., Berkovic, S. F., Dowling, J. P., Gonzales, M., Narayanan, S., Brodtmann, A., . . . Andermann, E. (2004). Action myoclonus-renal failure syndrome: Characterization of a unique cerebro-renal disorder. Brain : A Journal of Neurology, 127(Pt 10), 2173-2182. 10.1093/brain/awh263 Link to item
    • Banwell, B., Bar-Or, A., Arnold, D. L., Sadovnick, D., Narayanan, S., McGowan, M., . . . Marrie, R. A. (2011). Clinical, environmental, and genetic determinants of multiple sclerosis in children with acute demyelination: A prospective national cohort study. The Lancet.Neurology, 10(5), 436-445. 10.1016/S1474-4422(11)70045-X Link to item
    • Biernacki, K., Antel, J. P., Blain, M., Narayanan, S., Arnold, D. L., & Prat, A. (2005). Interferon beta promotes nerve growth factor secretion early in the course of multiple sclerosis. Archives of Neurology, 62(4), 563-568. 62/4/563 Link to item
    • Brass, S. D., Narayanan, S., Antel, J. P., Lapierre, Y., Collins, L., & Arnold, D. L. (2004). Axonal damage in multiple sclerosis patients with high versus low expanded disability status scale score. The Canadian Journal of Neurological Sciences.Le Journal Canadien Des Sciences Neurologiques, 31(2), 225-228. Link to item
    • Brown, R. A., Narayanan, S., & Arnold, D. L. (2013). Segmentation of magnetization transfer ratio lesions for longitudinal analysis of demyelination and remyelination in multiple sclerosis. Neuroimage, 66, 103-109. 10.1016/j.neuroimage.2012.10.059 Link to item
    • Brown, R. A., Narayanan, S., & Arnold, D. L. (2014). Imaging of repeated episodes of demyelination and remyelination in multiple sclerosis. NeuroImage.Clinical, 6, 20-25. 10.1016/j.nicl.2014.06.009 Link to item
    • Brown, R. A., Narayanan, S., Banwell, B., Arnold, D. L., & Canadian Pediatric Demyelinating Disease Network. (2014). Magnetization transfer ratio recovery in new lesions decreases during adolescence in pediatric-onset multiple sclerosis patients. NeuroImage.Clinical, 6, 237-242. 10.1016/j.nicl.2014.09.003 Link to item
    • Brown, R. A., Narayanan, S., Stikov, N., Cook, S., Cadavid, D., Wolansky, L., & Arnold, D. L. (2016). MTR recovery in brain lesions in the BECOME study of glatiramer acetate vs interferon beta-1b. Neurology, 87(9), 905-911. 10.1212/WNL.0000000000003043 Link to item
    • Campbell, J. S. W., Leppert, I. R., Narayanan, S., Boudreau, M., Duval, T., Cohen-Adad, J., . . . Stikov, N. (2017). Promise and pitfalls of g-ratio estimation with MRI. Neuroimage, S1053-8119(17)30685-7 Link to item
    • Caramanos, Z., DiMaio, S., Narayanan, S., Lapierre, Y., & Arnold, D. L. (2009). (1)H-MRSI evidence for cortical gray matter pathology that is independent of cerebral white matter lesion load in patients with secondary progressive multiple sclerosis. Journal of the Neurological Sciences, 282(1-2), 72-79. 10.1016/j.jns.2009.01.015 Link to item
    • Caramanos, Z., Fonov, V. S., Francis, S. J., Narayanan, S., Pike, G. B., Collins, D. L., & Arnold, D. L. (2010). Gradient distortions in MRI: Characterizing and correcting for their effects on SIENA-generated measures of brain volume change. Neuroimage, 49(2), 1601-1611. 10.1016/j.neuroimage.2009.08.008 Link to item
    • Caramanos, Z., Francis, S. J., Narayanan, S., Lapierre, Y., & Arnold, D. L. (2012). Large, nonplateauing relationship between clinical disability and cerebral white matter lesion load in patients with multiple sclerosis. Archives of Neurology, 69(1), 89-95. 10.1001/archneurol.2011.765 Link to item
    • Caramanos, Z., Narayanan, S., & Arnold, D. L. (2005). 1H-MRS quantification of tNA and tCr in patients with multiple sclerosis: A meta-analytic review. Brain : A Journal of Neurology, 128(Pt 11), 2483-2506. awh640 Link to item
    • De Stefano, N., Narayanan, S., Francis, S. J., Smith, S., Mortilla, M., Tartaglia, M. C., . . . Arnold, D. L. (2002). Diffuse axonal and tissue injury in patients with multiple sclerosis with low cerebral lesion load and no disability. Archives of Neurology, 59(10), 1565-1571. noc10304 Link to item
    • Derakhshan, M., Caramanos, Z., Giacomini, P. S., Narayanan, S., Maranzano, J., Francis, S. J., . . . Collins, D. L. (2010). Evaluation of automated techniques for the quantification of grey matter atrophy in patients with multiple sclerosis. Neuroimage, 52(4), 1261-1267. 10.1016/j.neuroimage.2010.05.029 Link to item
    • Derakhshan, M., Caramanos, Z., Narayanan, S., Arnold, D. L., & Louis Collins, D. (2014). Surface-based analysis reveals regions of reduced cortical magnetization transfer ratio in patients with multiple sclerosis: A proposed method for imaging subpial demyelination. Human Brain Mapping, 35(7), 3402-3413. 10.1002/hbm.22410 Link to item
    • Fuentes, A., Collins, D. L., Garcia-Lorenzo, D., Sled, J. G., Narayanan, S., Arnold, D. L., . . . Till, C. (2012). Memory performance and normalized regional brain volumes in patients with pediatric-onset multiple sclerosis. Journal of the International Neuropsychological Society : JINS, 18(3), 471-480. 10.1017/S1355617711001913 Link to item
    • Garcia-Lorenzo, D., Francis, S., Narayanan, S., Arnold, D. L., & Collins, D. L. (2013). Review of automatic segmentation methods of multiple sclerosis white matter lesions on conventional magnetic resonance imaging. Medical Image Analysis, 17(1), 1-18. 10.1016/j.media.2012.09.004 Link to item
    • Ghassemi, R., Antel, S. B., Narayanan, S., Francis, S. J., Bar-Or, A., Sadovnick, A. D., . . . Canadian Pediatric Demyelinating Disease Study Group. (2008). Lesion distribution in children with clinically isolated syndromes. Annals of Neurology, 63(3), 401-405. 10.1002/ana.21322 Link to item
    • Ghassemi, R., Brown, R., Banwell, B., Narayanan, S., Arnold, D. L., & Canadian Pediatric Demyelinating Disease Study Group. (2015). Quantitative measurement of tissue damage and recovery within new T2w lesions in pediatric- and adult-onset multiple sclerosis. Multiple Sclerosis (Houndmills, Basingstoke, England), 21(6), 718-725. 10.1177/1352458514551594 Link to item
    • Ghassemi, R., Brown, R., Narayanan, S., Banwell, B., Nakamura, K., & Arnold, D. L. (2015). Normalization of white matter intensity on T1-weighted images of patients with acquired central nervous system demyelination. Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging, 25(2), 184-190. 10.1111/jon.12129 Link to item
    • Ghassemi, R., Narayanan, S., Banwell, B., Sled, J. G., Shroff, M., Arnold, D. L., & Canadian Pediatric Demyelinating Disease Network. (2014). Quantitative determination of regional lesion volume and distribution in children and adults with relapsing-remitting multiple sclerosis. PloS One, 9(2), e85741. 10.1371/journal.pone.0085741 Link to item
    • Giacomini, P. S., Levesque, I. R., Ribeiro, L., Narayanan, S., Francis, S. J., Pike, G. B., & Arnold, D. L. (2009). Measuring demyelination and remyelination in acute multiple sclerosis lesion voxels. Archives of Neurology, 66(3), 375-381. 10.1001/archneurol.2008.578 Link to item
    • Lee, H., Nakamura, K., Narayanan, S., Brown, R., Chen, J., Atkins, H. L., . . . Arnold, D. L. (2017). Impact of immunoablation and autologous hematopoietic stem cell transplantation on gray and white matter atrophy in multiple sclerosis. Multiple Sclerosis (Houndmills, Basingstoke, England), , 1352458517715811. 10.1177/1352458517715811 Link to item
    • Lee, H., Narayanan, S., Brown, R. A., Chen, J. T., Atkins, H. L., Freedman, M. S., & Arnold, D. L. (2017). Brain atrophy after bone marrow transplantation for treatment of multiple sclerosis. Multiple Sclerosis (Houndmills, Basingstoke, England), 23(3), 420-431. 10.1177/1352458516650992 Link to item
    • Levesque, I., Sled, J. G., Narayanan, S., Santos, A. C., Brass, S. D., Francis, S. J., . . . Pike, G. B. (2005). The role of edema and demyelination in chronic T1 black holes: A quantitative magnetization transfer study. Journal of Magnetic Resonance Imaging : JMRI, 21(2), 103-110. 10.1002/jmri.20231 Link to item
    • Levesque, I. R., Giacomini, P. S., Narayanan, S., Ribeiro, L. T., Sled, J. G., Arnold, D. L., & Pike, G. B. (2010). Quantitative magnetization transfer and myelin water imaging of the evolution of acute multiple sclerosis lesions. Magnetic Resonance in Medicine, 63(3), 633-640. 10.1002/mrm.22244 Link to item
    • Levesque, I. R., Sled, J. G., Narayanan, S., Giacomini, P. S., Ribeiro, L. T., Arnold, D. L., & Pike, G. B. (2010). Reproducibility of quantitative magnetization-transfer imaging parameters from repeated measurements. Magnetic Resonance in Medicine, 64(2), 391-400. 10.1002/mrm.22350 Link to item
    • Longoni, G., Brown, R. A., MomayyezSiahkal, P., Elliott, C., Narayanan, S., Bar-Or, A., . . . Canadian Pediatric Demyelinating Disease Network. (2017). White matter changes in paediatric multiple sclerosis and monophasic demyelinating disorders. Brain : A Journal of Neurology, 140(5), 1300-1315. 10.1093/brain/awx041 Link to item
    • Maranzano, J., Rudko, D. A., Nakamura, K., Cook, S., Cadavid, D., Wolansky, L., . . . Narayanan, S. (2017). MRI evidence of acute inflammation in leukocortical lesions of patients with early multiple sclerosis. Neurology, 89(7), 714-721. 10.1212/WNL.0000000000004227 Link to item
    • Nakamura, K., Brown, R. A., Araujo, D., Narayanan, S., & Arnold, D. L. (2014). Correlation between brain volume change and T2 relaxation time induced by dehydration and rehydration: Implications for monitoring atrophy in clinical studies. NeuroImage.Clinical, 6, 166-170. 10.1016/j.nicl.2014.08.014 Link to item
    • Nakamura, K., Brown, R. A., Narayanan, S., Collins, D. L., Arnold, D. L., & Alzheimer’s Disease Neuroimaging Initiative. (2015). Diurnal fluctuations in brain volume: Statistical analyses of MRI from large populations. Neuroimage, 118, 126-132. 10.1016/j.neuroimage.2015.05.077 Link to item
    • Nakamura, K., Guizard, N., Fonov, V. S., Narayanan, S., Collins, D. L., & Arnold, D. L. (2013). Jacobian integration method increases the statistical power to measure gray matter atrophy in multiple sclerosis. NeuroImage.Clinical, 4, 10-17. 10.1016/j.nicl.2013.10.015 Link to item
    • Nantes, J. C., Proulx, S., Zhong, J., Holmes, S. A., Narayanan, S., Brown, R. A., . . . Koski, L. (2017). GABA and glutamate levels correlate with MTR and clinical disability: Insights from multiple sclerosis. Neuroimage, 157, 705-715. S1053-8119(17)30040-X Link to item
    • Nantes, J. C., Zhong, J., Holmes, S. A., Narayanan, S., Lapierre, Y., & Koski, L. (2016). Cortical damage and disability in multiple sclerosis: Relation to intracortical inhibition and facilitation. Brain Stimulation, 9(4), 566-573. 10.1016/j.brs.2016.01.003 Link to item
    • Nantes, J. C., Zhong, J., Holmes, S. A., Whatley, B., Narayanan, S., Lapierre, Y., . . . Koski, L. (2016). Intracortical inhibition abnormality during the remission phase of multiple sclerosis is related to upper limb dexterity and lesions. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 127(2), 1503-1511. S1388-2457(15)00762-2 Link to item
    • Nantes, J. C., Zhong, J., Holmes, S. A., Whatley, B., Narayanan, S., Lapierre, Y., . . . Koski, L. (2017). Corrigendum to “intracortical inhibition abnormality during the remission phase of multiple sclerosis is related to upper limb dexterity and lesions” [clin. neurophysiol. 127 (2016) 1503-1511. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 128(2), 393. S1388-2457(16)30998-1 Link to item
    • Narayanan, S., Francis, S. J., Sled, J. G., Santos, A. C., Antel, S., Levesque, I., . . . Arnold, D. L. (2006). Axonal injury in the cerebral normal-appearing white matter of patients with multiple sclerosis is related to concurrent demyelination in lesions but not to concurrent demyelination in normal-appearing white matter. Neuroimage, 29(2), 637-642. S1053-8119(05)00541-0 Link to item
    • Pomares, F. B., Funck, T., Feier, N. A., Roy, S., Daigle-Martel, A., Ceko, M., . . . Schweinhardt, P. (2017). Histological underpinnings of grey matter changes in fibromyalgia investigated using multimodal brain imaging. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 37(5), 1090-1101. 10.1523/JNEUROSCI.2619-16.2016 Link to item
    • Quintana, F. J., Patel, B., Yeste, A., Nyirenda, M., Kenison, J., Rahbari, R., . . . Canadian Pediatric Demyelinating Disease Network. (2014). Epitope spreading as an early pathogenic event in pediatric multiple sclerosis. Neurology, 83(24), 2219-2226. 10.1212/WNL.0000000000001066 Link to item
    • Rao, S. M., Losinski, G., Mourany, L., Schindler, D., Mamone, B., Reece, C., . . . Alberts, J. (2017). Processing speed test: Validation of a self-administered, iPad(®)-based tool for screening cognitive dysfunction in a clinic setting. Multiple Sclerosis (Houndmills, Basingstoke, England), 23(14), 1929-1937. 10.1177/1352458516688955 Link to item
    • Rudko, D. A., Derakhshan, M., Maranzano, J., Nakamura, K., Arnold, D. L., & Narayanan, S. (2016). Delineation of cortical pathology in multiple sclerosis using multi-surface magnetization transfer ratio imaging. NeuroImage.Clinical, 12, 858-868. 10.1016/j.nicl.2016.10.010 Link to item
    • Sadaka, Y., Verhey, L. H., Shroff, M. M., Branson, H. M., Arnold, D. L., Narayanan, S., . . . Canadian Pediatric Demyelinating Disease Network. (2012). 2010 McDonald criteria for diagnosing pediatric multiple sclerosis. Annals of Neurology, 72(2), 211-223. 10.1002/ana.23575 Link to item
    • Santos, A. C., Narayanan, S., de Stefano, N., Tartaglia, M. C., Francis, S. J., Arnaoutelis, R., . . . Arnold, D. L. (2002). Magnetization transfer can predict clinical evolution in patients with multiple sclerosis. Journal of Neurology, 249(6), 662-668. 10.1007/s00415-002-0686-4 Link to item
    • Stikov, N., Campbell, J. S., Stroh, T., Lavelee, M., Frey, S., Novek, J., . . . Pike, G. B. (2015). In vivo histology of the myelin g-ratio with magnetic resonance imaging. Neuroimage, 118, 397-405. 10.1016/j.neuroimage.2015.05.023 Link to item
    • Stikov, N., Campbell, J. S., Stroh, T., Lavelee, M., Frey, S., Novek, J., . . . Pike, G. B. (2015). Quantitative analysis of the myelin g-ratio from electron microscopy images of the macaque corpus callosum. Data in Brief, 4, 368-373. 10.1016/j.dib.2015.05.019 Link to item
    • Tartaglia, M. C., Narayanan, S., Francis, S. J., Santos, A. C., De Stefano, N., Lapierre, Y., & Arnold, D. L. (2004). The relationship between diffuse axonal damage and fatigue in multiple sclerosis. Archives of Neurology, 61(2), 201-207. 10.1001/archneur.61.2.201 Link to item
    • Till, C., Deotto, A., Tipu, V., Sled, J. G., Bethune, A., Narayanan, S., . . . Banwell, B. L. (2011). White matter integrity and math performance in pediatric multiple sclerosis: A diffusion tensor imaging study. Neuroreport, 22(18), 1005-1009. 10.1097/WNR.0b013e32834dc301 Link to item
    • Till, C., Noguera, A., Verhey, L. H., O’Mahony, J., Yeh, E. A., Mah, J. K., . . . Banwell, B. L. (2016). Cognitive and behavioral functioning in childhood acquired demyelinating syndromes. Journal of the International Neuropsychological Society : JINS, 22(10), 1050-1060. S1355617716000308 Link to item
    • Till, C., Racine, N., Araujo, D., Narayanan, S., Collins, D. L., Aubert-Broche, B., . . . Banwell, B. (2013). Changes in cognitive performance over a 1-year period in children and adolescents with multiple sclerosis. Neuropsychology, 27(2), 210-219. 10.1037/a0031665 Link to item
    • Trojan, D. A., Arnold, D. L., Shapiro, S., Bar-Or, A., Robinson, A., Le Cruguel, J. P., . . . Da Costa, D. (2009). Fatigue in post-poliomyelitis syndrome: Association with disease-related, behavioral, and psychosocial factors. PM & R : The Journal of Injury, Function, and Rehabilitation, 1(5), 442-449. 10.1016/j.pmrj.2009.03.003 Link to item
    • Trojan, D. A., Narayanan, S., Francis, S. J., Caramanos, Z., Robinson, A., Cardoso, M., & Arnold, D. L. (2014). Brain volume and fatigue in patients with postpoliomyelitis syndrome. PM & R : The Journal of Injury, Function, and Rehabilitation, 6(3), 215-220. 10.1016/j.pmrj.2013.09.009 Link to item
    • Verhey, L. H., Branson, H. M., Shroff, M. M., Callen, D. J., Sled, J. G., Narayanan, S., . . . Canadian Pediatric Demyelinating Disease Network. (2011). MRI parameters for prediction of multiple sclerosis diagnosis in children with acute CNS demyelination: A prospective national cohort study. The Lancet.Neurology, 10(12), 1065-1073. 10.1016/S1474-4422(11)70250-2 Link to item
    • Verhey, L. H., Narayanan, S., & Banwell, B. (2013). Standardized magnetic resonance imaging acquisition and reporting in pediatric multiple sclerosis. Neuroimaging Clinics of North America, 23(2), 217-26.e1-7. 10.1016/j.nic.2012.12.003 Link to item
    • Zhong, J., Nantes, J. C., Holmes, S. A., Gallant, S., Narayanan, S., & Koski, L. (2016). Abnormal functional connectivity and cortical integrity influence dominant hand motor disability in multiple sclerosis: A multimodal analysis. Human Brain Mapping, 37(12), 4262-4275. 10.1002/hbm.23307 Link to item

0 voters

Show results