Rick Hoge - profile revision

Dr. Richard Hoge is an Associate Professor in the Department of Neurology and Neurosurgery, and Director of the Human Magnetic Resonance (MRI) Program. Dr. Hoge is physicist who develops new brain imaging technology that is used to examine cognitive processes in the elderly. He creates programs for functional MRI and advanced positron emission tomography (PET) to study the state of brain function in both healthy and pathological subjects. He comes to the Neuro from the Université de Montréal, where he was associate director of the Functional Neuroimaging Unit CRIUGM and an associate professor at the Institute of Biomedical Engineering.

Dr. Hoge earned degrees in physics from Carleton University (BSc Honours, 1989) and from McGill University (MSc, 1996), and received a PhD in biomedical engineering also from McGill in 1999. He received further training as a postdoctoral fellow at Harvard University, where for five years he was an instructor in radiology and assistant physicist in the Department of Radiology at Massachusetts General Hospital…

His laboratory at The Neuro will study the impact of physiological changes, both normal and pathological, that occur in the brain during the course of aging. His research will involve use of one of the most powerful fMRI machines (7 tesla) currently available. His projects include creating innovative methods for imaging the delivery and consumption of oxygen in the brain.

Selected Publications

    • Garrett, D. D., Lindenberger, U., Hoge, R. D., & Gauthier, C. J. (2017). Age differences in brain signal variability are robust to multiple vascular controls. Scientific Reports, 7(1), 10149-017-09752-7. 10.1038/s41598-017-09752-7 Link to item
    • Lajoie, I., Nugent, S., Debacker, C., Dyson, K., Tancredi, F. B., Badhwar, A., . . . Hoge, R. D. (2017). Application of calibrated fMRI in alzheimer’s disease. NeuroImage.Clinical, 15, 348-358. 10.1016/j.nicl.2017.05.009 Link to item
    • Lajoie, I., Tancredi, F. B., & Hoge, R. D. (2017). The impact of inspired oxygen levels on calibrated fMRI measurements of M, OEF and resting CMRO2 using combined hypercapnia and hyperoxia. PloS One, 12(3), e0174932. 10.1371/journal.pone.0174932 Link to item
    • Nantes, J. C., Proulx, S., Zhong, J., Holmes, S. A., Narayanan, S., Brown, R. A., . . . Koski, L. (2017). GABA and glutamate levels correlate with MTR and clinical disability: Insights from multiple sclerosis. Neuroimage, 157, 705-715. S1053-8119(17)30040-X Link to item
    • Berman, A. J., Ma, Y., Hoge, R. D., & Pike, G. B. (2016). The effect of dissolved oxygen on the susceptibility of blood. Magnetic Resonance in Medicine, 75(1), 363-371. 10.1002/mrm.25571 Link to item
    • Lajoie, I., Tancredi, F. B., & Hoge, R. D. (2016). Regional reproducibility of BOLD calibration parameter M, OEF and resting-state CMRO2 measurements with QUO2 MRI. PloS One, 11(9), e0163071. 10.1371/journal.pone.0163071 Link to item
    • Dupuy, O., Gauthier, C. J., Fraser, S. A., Desjardins-Crepeau, L., Desjardins, M., Mekary, S., . . . Bherer, L. (2015). Higher levels of cardiovascular fitness are associated with better executive function and prefrontal oxygenation in younger and older women. Frontiers in Human Neuroscience, 9, 66. 10.3389/fnhum.2015.00066 Link to item
    • Gauthier, C. J., Lefort, M., Mekary, S., Desjardins-Crepeau, L., Skimminge, A., Iversen, P., . . . Hoge, R. D. (2015). Hearts and minds: Linking vascular rigidity and aerobic fitness with cognitive aging. Neurobiology of Aging, 36(1), 304-314. 10.1016/j.neurobiolaging.2014.08.018 Link to item
    • Tancredi, F. B., Girouard, H., & Hoge, R. D. (2015). Modeling the role of osmotic forces in the cerebrovascular response to CO2. Medical Hypotheses, 85(1), 25-36. 10.1016/j.mehy.2015.03.018 Link to item
    • Tancredi, F. B., Lajoie, I., & Hoge, R. D. (2015). Test-retest reliability of cerebral blood flow and blood oxygenation level-dependent responses to hypercapnia and hyperoxia using dual-echo pseudo-continuous arterial spin labeling and step changes in the fractional composition of inspired gases. Journal of Magnetic Resonance Imaging : JMRI, 42(4), 1144-1157. 10.1002/jmri.24878 Link to item
    • Tancredi, F. B., Lajoie, I., & Hoge, R. D. (2014). A simple breathing circuit allowing precise control of inspiratory gases for experimental respiratory manipulations. BMC Research Notes, 7, 235-0500-7-235. 10.1186/1756-0500-7-235 Link to item
    • Xu, X., Jerskey, B. A., Cote, D. M., Walsh, E. G., Hassenstab, J. J., Ladino, M. E., . . . Sweet, L. H. (2014). Cerebrovascular perfusion among older adults is moderated by strength training and gender. Neuroscience Letters, 560, 26-30. 10.1016/j.neulet.2013.12.011 Link to item
    • Barakat, M., Carrier, J., Debas, K., Lungu, O., Fogel, S., Vandewalle, G., . . . Doyon, J. (2013). Sleep spindles predict neural and behavioral changes in motor sequence consolidation. Human Brain Mapping, 34(11), 2918-2928. 10.1002/hbm.22116 Link to item
    • Gauthier, C. J., & Hoge, R. D. (2013). A generalized procedure for calibrated MRI incorporating hyperoxia and hypercapnia. Human Brain Mapping, 34(5), 1053-1069. 10.1002/hbm.21495 Link to item
    • Gauthier, C. J., Madjar, C., Desjardins-Crepeau, L., Bellec, P., Bherer, L., & Hoge, R. D. (2013). Age dependence of hemodynamic response characteristics in human functional magnetic resonance imaging. Neurobiology of Aging, 34(5), 1469-1485. 10.1016/j.neurobiolaging.2012.11.002 Link to item
    • Tancredi, F. B., & Hoge, R. D. (2013). Comparison of cerebral vascular reactivity measures obtained using breath-holding and CO2 inhalation. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism, 33(7), 1066-1074. 10.1038/jcbfm.2013.48 Link to item
    • Gagnon, L., Yucel, M. A., Dehaes, M., Cooper, R. J., Perdue, K. L., Selb, J., . . . Boas, D. A. (2012). Quantification of the cortical contribution to the NIRS signal over the motor cortex using concurrent NIRS-fMRI measurements. Neuroimage, 59(4), 3933-3940. 10.1016/j.neuroimage.2011.10.054 Link to item
    • Gauthier, C. J., Desjardins-Crepeau, L., Madjar, C., Bherer, L., & Hoge, R. D. (2012). Absolute quantification of resting oxygen metabolism and metabolic reactivity during functional activation using QUO2 MRI. Neuroimage, 63(3), 1353-1363. 10.1016/j.neuroimage.2012.07.065 Link to item
    • Gauthier, C. J., & Hoge, R. D. (2012). Magnetic resonance imaging of resting OEF and CMRO(2) using a generalized calibration model for hypercapnia and hyperoxia. Neuroimage, 60(2), 1212-1225. 10.1016/j.neuroimage.2011.12.056 Link to item
    • Hoge, R. D. (2012). Calibrated FMRI. Neuroimage, 62(2), 930-937. 10.1016/j.neuroimage.2012.02.022 Link to item
    • Madjar, C., Gauthier, C. J., Bellec, P., Birn, R. M., Brooks, J. C., & Hoge, R. D. (2012). Task-related BOLD responses and resting-state functional connectivity during physiological clamping of end-tidal CO(2). Neuroimage, 61(1), 41-49. 10.1016/j.neuroimage.2012.02.080 Link to item
    • Tancredi, F. B., Gauthier, C. J., Madjar, C., Bolar, D. S., Fisher, J. A., Wang, D. J., & Hoge, R. D. (2012). Comparison of pulsed and pseudocontinuous arterial spin-labeling for measuring CO2 -induced cerebrovascular reactivity. Journal of Magnetic Resonance Imaging : JMRI, 36(2), 312-321. 10.1002/jmri.23658 Link to item
    • Xie, G., Piche, M., Khoshnejad, M., Perlbarg, V., Chen, J. I., Hoge, R. D., . . . Cohen-Adad, J. (2012). Reduction of physiological noise with independent component analysis improves the detection of nociceptive responses with fMRI of the human spinal cord. Neuroimage, 63(1), 245-252. 10.1016/j.neuroimage.2012.06.057 Link to item
    • Gauthier, C. J., Madjar, C., Tancredi, F. B., Stefanovic, B., & Hoge, R. D. (2011). Elimination of visually evoked BOLD responses during carbogen inhalation: Implications for calibrated MRI. Neuroimage, 54(2), 1001-1011. 10.1016/j.neuroimage.2010.09.059 Link to item
    • Triantafyllou, C., Wald, L. L., & Hoge, R. D. (2011). Echo-time and field strength dependence of BOLD reactivity in veins and parenchyma using flow-normalized hypercapnic manipulation. PloS One, 6(9), e24519. 10.1371/journal.pone.0024519 Link to item
    • Cohen-Adad, J., Gauthier, C. J., Brooks, J. C., Slessarev, M., Han, J., Fisher, J. A., . . . Hoge, R. D. (2010). BOLD signal responses to controlled hypercapnia in human spinal cord. Neuroimage, 50(3), 1074-1084. 10.1016/j.neuroimage.2009.12.122 Link to item
    • Cohen-Adad, J., Hoge, R. D., Leblond, H., Xie, G., Beaudoin, G., Song, A. W., . . . Rossignol, S. (2009). Investigations on spinal cord fMRI of cats under ketamine. Neuroimage, 44(2), 328-339. 10.1016/j.neuroimage.2008.09.023 Link to item
    • Gasic, G. P., Smoller, J. W., Perlis, R. H., Sun, M., Lee, S., Kim, B. W., . . . Breiter, H. C. (2009). BDNF, relative preference, and reward circuitry responses to emotional communication. American Journal of Medical Genetics.Part B, Neuropsychiatric Genetics : The Official Publication of the International Society of Psychiatric Genetics, 150B(6), 762-781. 10.1002/ajmg.b.30944 Link to item
    • Cohen-Adad, J., Benali, H., Hoge, R. D., & Rossignol, S. (2008). In vivo DTI of the healthy and injured cat spinal cord at high spatial and angular resolution. Neuroimage, 40(2), 685-697. S1053-8119(07)01057-9 Link to item
    • Cohen-Adad, J., Descoteaux, M., Rossignol, S., Hoge, R. D., Deriche, R., & Benali, H. (2008). Detection of multiple pathways in the spinal cord using q-ball imaging. Neuroimage, 42(2), 739-749. 10.1016/j.neuroimage.2008.04.243 Link to item
    • Gagnon, L., Gauthier, C., Hoge, R. D., Lesage, F., Selb, J., & Boas, D. A. (2008). Double-layer estimation of intra- and extracerebral hemoglobin concentration with a time-resolved system. Journal of Biomedical Optics, 13(5), 054019. 10.1117/1.2982524 Link to item
    • Gauthier, C., & Hoge, R. D. (2008). BOLD-perfusion coupling during monocular and binocular stimulation. International Journal of Biomedical Imaging, 2008, 628718. 10.1155/2008/628718 Link to item
    • Huppert, T. J., Hoge, R. D., Dale, A. M., Franceschini, M. A., & Boas, D. A. (2006). Quantitative spatial comparison of diffuse optical imaging with blood oxygen level-dependent and arterial spin labeling-based functional magnetic resonance imaging. Journal of Biomedical Optics, 11(6), 064018. 10.1117/1.2400910 Link to item
    • Huppert, T. J., Hoge, R. D., Diamond, S. G., Franceschini, M. A., & Boas, D. A. (2006). A temporal comparison of BOLD, ASL, and NIRS hemodynamic responses to motor stimuli in adult humans. Neuroimage, 29(2), 368-382. S1053-8119(05)00582-3 Link to item
    • Triantafyllou, C., Hoge, R. D., & Wald, L. L. (2006). Effect of spatial smoothing on physiological noise in high-resolution fMRI. Neuroimage, 32(2), 551-557. S1053-8119(06)00480-0 Link to item
    • Hoge, R. D., Franceschini, M. A., Covolan, R. J., Huppert, T., Mandeville, J. B., & Boas, D. A. (2005). Simultaneous recording of task-induced changes in blood oxygenation, volume, and flow using diffuse optical imaging and arterial spin-labeling MRI. Neuroimage, 25(3), 701-707. S1053-8119(04)00790-6 Link to item
    • Triantafyllou, C., Hoge, R. D., Krueger, G., Wiggins, C. J., Potthast, A., Wiggins, G. C., & Wald, L. L. (2005). Comparison of physiological noise at 1.5 T, 3 T and 7 T and optimization of fMRI acquisition parameters. Neuroimage, 26(1), 243-250. S1053-8119(05)00033-9 Link to item
    • Boas, D. A., Strangman, G., Culver, J. P., Hoge, R. D., Jasdzewski, G., Poldrack, R. A., . . . Mandeville, J. B. (2003). Can the cerebral metabolic rate of oxygen be estimated with near-infrared spectroscopy? Physics in Medicine and Biology, 48(15), 2405-2418. Link to item
    • Dumoulin, S. O., Hoge, R. D., Baker, C. L.,Jr, Hess, R. F., Achtman, R. L., & Evans, A. C. (2003). Automatic volumetric segmentation of human visual retinotopic cortex. Neuroimage, 18(3), 576-587. S1053811902000587 Link to item
    • Hoge, R. D., & Pike, G. B. (2001). Oxidative metabolism and the detection of neuronal activation via imaging. Journal of Chemical Neuroanatomy, 22(1-2), 43-52. S0891-0618(01)00114-4 Link to item
    • Reddy, H., Narayanan, S., Matthews, P. M., Hoge, R. D., Pike, G. B., Duquette, P., . . . Arnold, D. L. (2000). Relating axonal injury to functional recovery in MS. Neurology, 54(1), 236-239. Link to item
    • Crelier, G. R., Hoge, R. D., Munger, P., & Pike, G. B. (1999). Perfusion-based functional magnetic resonance imaging with single-shot RARE and GRASE acquisitions. Magnetic Resonance in Medicine, 41(1), 132-136. 10.1002/(SICI)1522-2594(199901)41:1<132::AID-MRM18>3.0.CO;2-5 Link to item
    • Hoge, R. D., Atkinson, J., Gill, B., Crelier, G. R., Marrett, S., & Pike, G. B. (1999). Investigation of BOLD signal dependence on cerebral blood flow and oxygen consumption: The deoxyhemoglobin dilution model. Magnetic Resonance in Medicine, 42(5), 849-863. 10.1002/(SICI)1522-2594(199911)42:5<849::AID-MRM4>3.0.CO;2-Z Link to item
    • Hoge, R. D., Kwan, R. K., & Pike, G. B. (1997). Density compensation functions for spiral MRI. Magnetic Resonance in Medicine, 38(1), 117-128. Link to item
    • Hoge, R. D., & Lanzetta, J. T. (1968). Effects of response uncertainty and degree of knowledge on subjective uncertainty. Psychological Reports, 22(3), 1081-1090. 10.2466/pr0.1968.22.3c.1081 Link to item
    • Hoge, R. D., Atkinson, J., Gill, B., Crelier, G. R., Marrett, S., & Pike, G. B. (1999). Stimulus-dependent BOLD and perfusion dynamics in human V1. Neuroimage, 9(6 Pt 1), 573-585. S1053-8119(99)90443-3 Link to item
    • Hoge, R. D., Andrews, D. A., Faulkner, P., & Robinson, D. (1989). The family relationship index: Validity data. Journal of Clinical Psychology, 45(6), 897-903. Link to item
    • Hoge, R. D., Andrews, D. A., & Leschied, A. W. (1994). Tests of three hypotheses regarding the predictors of delinquency. Journal of Abnormal Child Psychology, 22(5), 547-559. Link to item
    • Hoge, R. D., Andrews, D. A., & Leschied, L. W. (1996). An investigation of risk and protective factors in a sample of youthful offenders. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 37(4), 419-424. Link to item
    • Hoge, R. D., Andrews, D. A., Robinson, D., & Hollett, J. (1988). The construct validity of interview-based assessments in family counseling. Journal of Clinical Psychology, 44(4), 563-572. Link to item
    • Hoge, R. D., Atkinson, J., Gill, B., Crelier, G. R., Marrett, S., & Pike, G. B. (1999). Linear coupling between cerebral blood flow and oxygen consumption in activated human cortex. Proceedings of the National Academy of Sciences of the United States of America, 96(16), 9403-9408. Link to item
    • Hoge, R. D., Meginbir, L., Khan, Y., & Weatherall, D. (1985). A multitrait-multimethod analysis of the preschool behavior questionnaire. Journal of Abnormal Child Psychology, 13(1), 119-127. Link to item
    • PRUITT, D. G., & HOGE, R. D. (1965). Strength of the relationship between the value of an event and its subjective probability as a function of method of measurement. Journal of Experimental Psychology, 69, 483-489. Link to item

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