Pedro Rosa-Neto - profile creation

Biographical + Research statement: TBD.

Selected Publications

    • Benedet, A. L., Yu, L., Labbe, A., Mathotaarachchi, S., Pascoal, T. A., Shin, M., . . . Alzheimer’s Disease Neuroimaging Initiative. (2018). CYP2C19 variant mitigates alzheimer disease pathophysiology in vivo and postmortem. Neurology.Genetics, 4(1), e216. 10.1212/NXG.0000000000000216 Link to item
    • Bernard-Gauthier, V., Mossine, A. V., Mahringer, A., Aliaga, A., Bailey, J. J., Shao, X., . . . Schirrmacher, R. (2018). Identification of [(18)F]TRACK, a fluorine-18-labeled tropomyosin receptor kinase (trk) inhibitor for PET imaging. Journal of Medicinal Chemistry, 61(4), 1737-1743. 10.1021/acs.jmedchem.7b01607 Link to item
    • Gauthier, S., Ng, K. P., Pascoal, T. A., Zhang, H., & Rosa-Neto, P. (2018). Targeting alzheimer’s disease at the right time and the right place: Validation of a personalized approach to diagnosis and treatment. Journal of Alzheimer’s Disease : JAD, 10.3233/JAD-179924 Link to item
    • Henriques, A. D., Benedet, A. L., Camargos, E. F., Rosa-Neto, P., & Nobrega, O. T. (2018). Fluid and imaging biomarkers for alzheimer’s disease: Where we stand and where to head to. Experimental Gerontology, S0531-5565(17)30411-4 Link to item
    • Pascoal, T. A., Mathotaarachchi, S., Shin, M., Park, A. Y., Mohades, S., Benedet, A. L., . . . Alzheimer’s Disease Neuroimaging Initiative. (2018). Amyloid and tau signatures of brain metabolic decline in preclinical alzheimer’s disease. European Journal of Nuclear Medicine and Molecular Imaging, 10.1007/s00259-018-3933-3 Link to item
    • Tardif, C. L., Devenyi, G. A., Amaral, R. S. C., Pelleieux, S., Poirier, J., Rosa-Neto, P., . . . PREVENT-AD Research Group. (2018). Regionally specific changes in the hippocampal circuitry accompany progression of cerebrospinal fluid biomarkers in preclinical alzheimer’s disease. Human Brain Mapping, 39(2), 971-984. 10.1002/hbm.23897 Link to item
    • Therriault, J., Ng, K. P., Pascoal, T. A., Mathotaarachchi, S., Kang, M. S., Struyfs, H., . . . Alzheimer’s Disease Neuroimaging Initiative. (2018). Anosognosia predicts default mode network hypometabolism and clinical progression to dementia. Neurology, 90(11), e932-e939. 10.1212/WNL.0000000000005120 Link to item
    • Villeneuve, S., Vogel, J. W., Gonneaud, J., Pichet Binette, A., Rosa-Neto, P., Gauthier, S., . . . Presymptomatic Evaluation of Novel or Experimental Treatments for Alzheimer Disease (PREVENT-AD) Research Group. (2018). Proximity to parental symptom onset and amyloid-beta burden in sporadic alzheimer disease. JAMA Neurology, 10.1001/jamaneurol.2017.5135 Link to item
    • Aghourian, M., Legault-Denis, C., Soucy, J. P., Rosa-Neto, P., Gauthier, S., Kostikov, A., . . . Bedard, M. A. (2017). Quantification of brain cholinergic denervation in alzheimer’s disease using PET imaging with [(18)F]-FEOBV. Molecular Psychiatry, 22(11), 1531-1538. 10.1038/mp.2017.183 Link to item
    • Ba, M., Li, X., Ng, K. P., Pascoal, T. A., Mathotaarachchi, S., Rosa-Neto, P., . . . Alzheimer’s Disease Neuroimaging Initiative. (2017). The prevalence and biomarkers’ characteristic of rapidly progressive alzheimer’s disease from the alzheimer’s disease neuroimaging initiative database. Alzheimer’s & Dementia (New York, N.Y.), 3(1), 107-113. 10.1016/j.trci.2016.12.005 Link to item
    • Bernard-Gauthier, V., Bailey, J. J., Mossine, A. V., Lindner, S., Vomacka, L., Aliaga, A., . . . Scott, P. J. H. (2017). A kinome-wide selective radiolabeled TrkB/C inhibitor for in vitro and in vivo neuroimaging: Synthesis, preclinical evaluation, and first-in-human. Journal of Medicinal Chemistry, 60(16), 6897-6910. 10.1021/acs.jmedchem.7b00396 Link to item
    • Chamoun, M., Huppe-Gourgues, F., Legault, I., Rosa-Neto, P., Dumbrava, D., Faubert, J., & Vaucher, E. (2017). Cholinergic potentiation improves perceptual-cognitive training of healthy young adults in three dimensional multiple object tracking. Frontiers in Human Neuroscience, 11, 128. 10.3389/fnhum.2017.00128 Link to item
    • Dadar, M., Pascoal, T. A., Manitsirikul, S., Misquitta, K., Fonov, V. S., Tartaglia, M. C., . . . Collins, D. L. (2017). Validation of a regression technique for segmentation of white matter hyperintensities in alzheimer’s disease. IEEE Transactions on Medical Imaging, 36(8), 1758-1768. 10.1109/TMI.2017.2693978 Link to item
    • Engelborghs, S., Niemantsverdriet, E., Struyfs, H., Blennow, K., Brouns, R., Comabella, M., . . . Teunissen, C. E. (2017). Consensus guidelines for lumbar puncture in patients with neurological diseases. Alzheimer’s & Dementia (Amsterdam, Netherlands), 8, 111-126. 10.1016/j.dadm.2017.04.007 Link to item
    • Gauthier, S., Ng, K. P., Pascoal, T. A., Mathotaarachchi, S., Chung, C. O., Benedetti, A. L., . . . Rosa-Neto, P. (2017). Author response: Neuropsychiatric symptoms predict hypometabolism in preclinical alzheimer disease. Neurology, 89(18), 1931. 10.1212/WNL.0000000000004593 Link to item
    • Lafaille-Magnan, M. E., Poirier, J., Etienne, P., Tremblay-Mercier, J., Frenette, J., Rosa-Neto, P., . . . PREVENT-AD Research Group. (2017). Odor identification as a biomarker of preclinical AD in older adults at risk. Neurology, 89(4), 327-335. 10.1212/WNL.0000000000004159 Link to item
    • Li, X., Ba, M., Ng, K. P., Mathotaarachchi, S., Pascoal, T. A., Rosa-Neto, P., & Gauthier, S. (2017). Characterizing biomarker features of cognitively normal individuals with ventriculomegaly. Alzheimer’s & Dementia (Amsterdam, Netherlands), 10, 12-21. 10.1016/j.dadm.2017.08.001 Link to item
    • Mathotaarachchi, S., Pascoal, T. A., Shin, M., Benedet, A. L., Kang, M. S., Beaudry, T., . . . Alzheimer’s Disease Neuroimaging Initiative. (2017). Identifying incipient dementia individuals using machine learning and amyloid imaging. Neurobiology of Aging, 59, 80-90. S0197-4580(17)30229-4 Link to item
    • Ng, K. P., Pascoal, T. A., Mathotaarachchi, S., Chung, C. O., Benedet, A. L., Shin, M., . . . Alzheimer’s Disease Neuroimaging Initiative. (2017). Neuropsychiatric symptoms predict hypometabolism in preclinical alzheimer disease. Neurology, 88(19), 1814-1821. 10.1212/WNL.0000000000003916 Link to item
    • Ng, K. P., Pascoal, T. A., Mathotaarachchi, S., Therriault, J., Kang, M. S., Shin, M., . . . Rosa-Neto, P. (2017). Monoamine oxidase B inhibitor, selegiline, reduces (18)F-THK5351 uptake in the human brain. Alzheimer’s Research & Therapy, 9(1), 25-017-0253-y. 10.1186/s13195-017-0253-y Link to item
    • Parent, M. J., Zimmer, E. R., Shin, M., Kang, M. S., Fonov, V. S., Mathieu, A., . . . Rosa-Neto, P. (2017). Multimodal imaging in rat model recapitulates alzheimer’s disease biomarkers abnormalities. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 37(50), 12263-12271. 10.1523/JNEUROSCI.1346-17.2017 Link to item
    • Pascoal, T. A., Mathotaarachchi, S., Mohades, S., Benedet, A. L., Chung, C. O., Shin, M., . . . Rosa-Neto, P. (2017). Amyloid-beta and hyperphosphorylated tau synergy drives metabolic decline in preclinical alzheimer’s disease. Molecular Psychiatry, 22(2), 306-311. 10.1038/mp.2016.37 Link to item
    • Pascoal, T. A., Mathotaarachchi, S., Shin, M., Benedet, A. L., Mohades, S., Wang, S., . . . Alzheimer’s Disease Neuroimaging Initiative. (2017). Synergistic interaction between amyloid and tau predicts the progression to dementia. Alzheimer’s & Dementia : The Journal of the Alzheimer’s Association, 13(6), 644-653. S1552-5260(16)33104-1 Link to item
    • Tuwaig, M., Savard, M., Jutras, B., Poirier, J., Collins, D. L., Rosa-Neto, P., . . . PREVENT-AD Research Group. (2017). Deficit in central auditory processing as a biomarker of pre-clinical alzheimer’s disease. Journal of Alzheimer’s Disease : JAD, 60(4), 1589-1600. 10.3233/JAD-170545 Link to item
    • Zimmer, E. R., Parent, M. J., Souza, D. G., Leuzy, A., Lecrux, C., Kim, H. I., . . . Rosa-Neto, P. (2017). (18)F]FDG PET signal is driven by astroglial glutamate transport. Nature Neuroscience, 20(3), 393-395. 10.1038/nn.4492 Link to item
    • Ba, M., Kong, M., Li, X., Ng, K. P., Rosa-Neto, P., & Gauthier, S. (2016). Is ApoE varepsilon 4 a good biomarker for amyloid pathology in late onset alzheimer’s disease? Translational Neurodegeneration, 5, 20-016-0067-z. eCollection 2016. 10.1186/s40035-016-0067-z Link to item
    • Cho, J., Kwon, D. H., Kim, R. G., Song, H., Rosa-Neto, P., Lee, M. C., & Kim, H. I. (2016). Remodeling of neuronal circuits after reach training in chronic capsular stroke. Neurorehabilitation and Neural Repair, 30(10), 941-950. 1545968316650282 Link to item
    • DuBois, J. M., Rousset, O. G., Guiot, M. C., Hall, J. A., Reader, A. J., Soucy, J. P., . . . Kobayashi, E. (2016). Metabotropic glutamate receptor type 5 (mGluR5) cortical abnormalities in focal cortical dysplasia identified in vivo with [11C]ABP688 positron-emission tomography (PET) imaging. Cerebral Cortex (New York, N.Y.: 1991), 26(11), 4170-4179. 10.1093/cercor/bhw249 Link to item
    • DuBois, J. M., Rousset, O. G., Rowley, J., Porras-Betancourt, M., Reader, A. J., Labbe, A., . . . Kobayashi, E. (2016). Characterization of age/sex and the regional distribution of mGluR5 availability in the healthy human brain measured by high-resolution [(11)C]ABP688 PET. European Journal of Nuclear Medicine and Molecular Imaging, 43(1), 152-162. 10.1007/s00259-015-3167-6 Link to item
    • Gauthier, S., Rosa-Neto, P., & Kass, J. S. (2016). Ethical considerations for the use of next-generation alzheimer drugs in symptomatic and at-risk patients. Continuum (Minneapolis, Minn.), 22(2 Dementia), 615-618. 10.1212/CON.0000000000000306 Link to item
    • Gibon, J., Kang, M. S., Aliaga, A., Sharif, B., Rosa-Neto, P., Seguela, P., . . . Kostikov, A. (2016). Towards the PET radiotracer for p75 neurotrophin receptor: [(11)C]LM11A-24 shows biological activity in vitro, but unfavorable ex vivo and in vivo profile. Bioorganic & Medicinal Chemistry, 24(19), 4759-4765. S0968-0896(16)30627-7 Link to item
    • Kim, R. G., Cho, J., Ree, J., Kim, H. S., Rosa-Neto, P., Kim, J. M., . . . Kim, H. I. (2016). Sensory-parietal cortical stimulation improves motor recovery in severe capsular infarct. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism, 36(12), 2211-2222. 0271678X15606136 Link to item
    • Laforce, R., Rosa-Neto, P., Soucy, J. P., Rabinovici, G. D., Dubois, B., & Gauthier, S. (2016). Canadian consensus guidelines on use of amyloid imaging in canada: Update and future directions from the specialized task force on amyloid imaging in canada. The Canadian Journal of Neurological Sciences.Le Journal Canadien Des Sciences Neurologiques, 43(4), 503-512. 10.1017/cjn.2015.401 Link to item
    • Leuzy, A., Zimmer, E. R., Dubois, J., Pruessner, J., Cooperman, C., Soucy, J. P., . . . Rosa-Neto, P. (2016). In vivo characterization of metabotropic glutamate receptor type 5 abnormalities in behavioral variant FTD. Brain Structure & Function, 221(3), 1387-1402. 10.1007/s00429-014-0978-3 Link to item
    • Mathotaarachchi, S., Wang, S., Shin, M., Pascoal, T. A., Benedet, A. L., Kang, M. S., . . . Rosa-Neto, P. (2016). VoxelStats: A MATLAB package for multi-modal voxel-wise brain image analysis. Frontiers in Neuroinformatics, 10, 20. 10.3389/fninf.2016.00020 Link to item
    • Mechling, A. E., Arefin, T., Lee, H. L., Bienert, T., Reisert, M., Ben Hamida, S., . . . Harsan, L. A. (2016). Deletion of the mu opioid receptor gene in mice reshapes the reward-aversion connectome. Proceedings of the National Academy of Sciences of the United States of America, 113(41), 11603-11608. 1601640113 Link to item
    • Schilling, L. P., Zimmer, E. R., Shin, M., Leuzy, A., Pascoal, T. A., Benedet, A. L., . . . Rosa-Neto, P. (2016). Imaging alzheimer’s disease pathophysiology with PET. Dementia & Neuropsychologia, 10(2), 79-90. 10.1590/S1980-5764-2016DN1002003 Link to item
    • Tam, A., Dansereau, C., Badhwar, A., Orban, P., Belleville, S., Chertkow, H., . . . Alzheimers Disease Neuroimaging Initiative. (2016). A dataset of multiresolution functional brain parcellations in an elderly population with no or mild cognitive impairment. Data in Brief, 9, 1122-1129. 10.1016/j.dib.2016.11.036 Link to item
    • Tomaszewski, S., Gauthier, S., Wimo, A., & Rosa-Neto, P. (2016). Combination therapy of anti-tau and anti-amyloid drugs for disease modification in early-stage alzheimer’s disease: Socio-economic considerations modeled on treatments for tuberculosis, HIV/AIDS and breast cancer. The Journal of Prevention of Alzheimer’s Disease, 3(3), 164-172. 10.14283/jpad.2015.85 Link to item
    • Turgeon, M., Oualkacha, K., Ciampi, A., Miftah, H., Dehghan, G., Zanke, B. W., . . . Alzheimer’s Disease Neuroimaging Initiative. (2016). Principal component of explained variance: An efficient and optimal data dimension reduction framework for association studies. Statistical Methods in Medical Research, 0962280216660128 Link to item
    • Benedet, A. L., Labbe, A., Lemay, P., Zimmer, E. R., Pascoal, T. A., Leuzy, A., . . . Alzheimer’s Disease Neuroimaging Initiative. (2015). Epistasis analysis links immune cascades and cerebral amyloidosis. Journal of Neuroinflammation, 12, 227-015-0436-z. 10.1186/s12974-015-0436-z Link to item
    • Bernard-Gauthier, V., Aliaga, A., Aliaga, A., Boudjemeline, M., Hopewell, R., Kostikov, A., . . . Schirrmacher, R. (2015). Syntheses and evaluation of carbon-11- and fluorine-18-radiolabeled pan-tropomyosin receptor kinase (trk) inhibitors: Exploration of the 4-aza-2-oxindole scaffold as trk PET imaging agents. ACS Chemical Neuroscience, 6(2), 260-276. 10.1021/cn500193f Link to item
    • Cyr, M., Parent, M. J., Mechawar, N., Rosa-Neto, P., Soucy, J. P., Clark, S. D., . . . Bedard, M. A. (2015). Deficit in sustained attention following selective cholinergic lesion of the pedunculopontine tegmental nucleus in rat, as measured with both post-mortem immunocytochemistry and in vivo PET imaging with [(1)(8)F]fluoroethoxybenzovesamicol. Behavioural Brain Research, 278, 107-114. 10.1016/j.bbr.2014.09.021 Link to item
    • Orban, P., Madjar, C., Savard, M., Dansereau, C., Tam, A., Das, S., . . . PREVENT-AD Research Group. (2015). Test-retest resting-state fMRI in healthy elderly persons with a family history of alzheimer’s disease. Scientific Data, 2, 150043. 10.1038/sdata.2015.43 Link to item
    • Tam, A., Dansereau, C., Badhwar, A., Orban, P., Belleville, S., Chertkow, H., . . . Alzheimer’s Disease Neuroimaging Initiative. (2015). Common effects of amnestic mild cognitive impairment on resting-state connectivity across four independent studies. Frontiers in Aging Neuroscience, 7, 242. 10.3389/fnagi.2015.00242 Link to item
    • Zimmer, E. R., Parent, M. J., Leuzy, A., Aliaga, A., Aliaga, A., Moquin, L., . . . Rosa-Neto, P. (2015). Imaging in vivo glutamate fluctuations with [(11)C]ABP688: A GLT-1 challenge with ceftriaxone. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism, 35(7), 1169-1174. 10.1038/jcbfm.2015.35 Link to item
    • Cyr, M., Parent, M. J., Mechawar, N., Rosa-Neto, P., Soucy, J. P., Aliaga, A., . . . Bedard, M. A. (2014). PET imaging with [(1)(8)F]fluoroethoxybenzovesamicol ([(1)(8)F]FEOBV) following selective lesion of cholinergic pedunculopontine tegmental neurons in rat. Nuclear Medicine and Biology, 41(1), 96-101. 10.1016/j.nucmedbio.2013.10.004 Link to item
    • Gauthier, S., Leuzy, A., & Rosa-Neto, P. (2014). How can we improve transfer of outcomes from randomized clinical trials to clinical practice with disease-modifying drugs in alzheimer’s disease? Neuro-Degenerative Diseases, 13(2-3), 197-199. 10.1159/000353748 Link to item
    • Leuzy, A., Zimmer, E. R., Bhat, V., Rosa-Neto, P., & Gauthier, S. (2014). Imaging biomarkers for amyloid: A new generation of probes and what lies ahead. International Psychogeriatrics, 26(5), 703-707. 10.1017/S1041610214000118 Link to item
    • Leuzy, A., Zimmer, E. R., Heurling, K., Rosa-Neto, P., & Gauthier, S. (2014). Use of amyloid PET across the spectrum of alzheimer’s disease: Clinical utility and associated ethical issues. Amyloid : The International Journal of Experimental and Clinical Investigation : The Official Journal of the International Society of Amyloidosis, 21(3), 143-148. 10.3109/13506129.2014.926267 Link to item
    • Milella, M. S., Marengo, L., Larcher, K., Fotros, A., Dagher, A., Rosa-Neto, P., . . . Leyton, M. (2014). Limbic system mGluR5 availability in cocaine dependent subjects: A high-resolution PET [(11)C]ABP688 study. Neuroimage, 98, 195-202. 10.1016/j.neuroimage.2014.04.061 Link to item
    • Ongali, B., Nicolakakis, N., Tong, X. K., Aboulkassim, T., Papadopoulos, P., Rosa-Neto, P., . . . Hamel, E. (2014). Angiotensin II type 1 receptor blocker losartan prevents and rescues cerebrovascular, neuropathological and cognitive deficits in an alzheimer’s disease model. Neurobiology of Disease, 68, 126-136. 10.1016/j.nbd.2014.04.018 Link to item
    • Wu, L., Soder, R. B., Schoemaker, D., Carbonnell, F., Sziklas, V., Rowley, J., . . . Rosa-Neto, P. (2014). Resting state executive control network adaptations in amnestic mild cognitive impairment. Journal of Alzheimer’s Disease : JAD, 40(4), 993-1004. 10.3233/JAD-131574 Link to item
    • Zimmer, E. R., Leuzy, A., Benedet, A. L., Breitner, J., Gauthier, S., & Rosa-Neto, P. (2014). Tracking neuroinflammation in alzheimer’s disease: The role of positron emission tomography imaging. Journal of Neuroinflammation, 11, 120-2094-11-120. 10.1186/1742-2094-11-120 Link to item
    • Zimmer, E. R., Leuzy, A., Bhat, V., Gauthier, S., & Rosa-Neto, P. (2014). In vivo tracking of tau pathology using positron emission tomography (PET) molecular imaging in small animals. Translational Neurodegeneration, 3(1), 6-9158-3-6. 10.1186/2047-9158-3-6 Link to item
    • Zimmer, E. R., Leuzy, A., Gauthier, S., & Rosa-Neto, P. (2014). Developments in tau PET imaging. The Canadian Journal of Neurological Sciences.Le Journal Canadien Des Sciences Neurologiques, 41(5), 547-553. 10.1017/cjn.2014.15 Link to item
    • Zimmer, E. R., Parent, M. J., Cuello, A. C., Gauthier, S., & Rosa-Neto, P. (2014). MicroPET imaging and transgenic models: A blueprint for alzheimer’s disease clinical research. Trends in Neurosciences, 37(11), 629-641. 10.1016/j.tins.2014.07.002 Link to item
    • Bernard-Gauthier, V., Boudjemeline, M., Rosa-Neto, P., Thiel, A., & Schirrmacher, R. (2013). Towards tropomyosin-related kinase B (TrkB) receptor ligands for brain imaging with PET: Radiosynthesis and evaluation of 2-(4-[(18)F]fluorophenyl)-7,8-dihydroxy-4H-chromen-4-one and 2-(4-([N-methyl-(11)C]-dimethylamino)phenyl)-7,8-dihydroxy-4H-chromen-4-one. Bioorganic & Medicinal Chemistry, 21(24), 7816-7829. 10.1016/j.bmc.2013.10.012 Link to item
    • Burhan, A. M., Bartha, R., Bocti, C., Borrie, M., Laforce, R., Rosa-Neto, P., & Soucy, J. P. (2013). Role of emerging neuroimaging modalities in patients with cognitive impairment: A review from the canadian consensus conference on the diagnosis and treatment of dementia 2012. Alzheimer’s Research & Therapy, 5(Suppl 1), S4. 10.1186/alzrt200 Link to item
    • Gauthier, S., Leuzy, A., Racine, E., & Rosa-Neto, P. (2013). Diagnosis and management of alzheimer’s disease: Past, present and future ethical issues. Progress in Neurobiology, 110, 102-113. 10.1016/j.pneurobio.2013.01.003 Link to item
    • Gauthier, S., & Rosa-Neto, P. (2013). Dementia: Disclosure of results to participants in dementia research. Nature Reviews.Neurology, 9(11), 608-609. 10.1038/nrneurol.2013.213 Link to item
    • Kandratavicius, L., Rosa-Neto, P., Monteiro, M. R., Guiot, M. C., Assirati, J. A.,Jr, Carlotti, C. G.,Jr, . . . Leite, J. P. (2013). Distinct increased metabotropic glutamate receptor type 5 (mGluR5) in temporal lobe epilepsy with and without hippocampal sclerosis. Hippocampus, 23(12), 1212-1230. 10.1002/hipo.22160 Link to item
    • Papadopoulos, P., Rosa-Neto, P., Rochford, J., & Hamel, E. (2013). Pioglitazone improves reversal learning and exerts mixed cerebrovascular effects in a mouse model of alzheimer’s disease with combined amyloid-beta and cerebrovascular pathology. PloS One, 8(7), e68612. 10.1371/journal.pone.0068612 Link to item
    • Parent, M. J., Bedard, M. A., Aliaga, A., Minuzzi, L., Mechawar, N., Soucy, J. P., . . . Rosa-Neto, P. (2013). Cholinergic depletion in alzheimer’s disease shown by [ (18) F]FEOBV autoradiography. International Journal of Molecular Imaging, 2013, 205045. 10.1155/2013/205045 Link to item
    • Parent, M. J., Cyr, M., Aliaga, A., Kostikov, A., Schirrmacher, E., Soucy, J. P., . . . Bedard, M. A. (2013). Concordance between in vivo and postmortem measurements of cholinergic denervation in rats using PET with [18F]FEOBV and choline acetyltransferase immunochemistry. EJNMMI Research, 3(1), 70-219X-3-70. 10.1186/2191-219X-3-70 Link to item
    • Rosa-Neto, P., Hsiung, G. Y., Masellis, M., & CCDTD4 participants. (2013). Fluid biomarkers for diagnosing dementia: Rationale and the canadian consensus on diagnosis and treatment of dementia recommendations for canadian physicians. Alzheimer’s Research & Therapy, 5(Suppl 1), S8. 10.1186/alzrt223 Link to item
    • Rowley, J., Fonov, V., Wu, O., Eskildsen, S. F., Schoemaker, D., Wu, L., . . . Alzheimer’s Disease Neuroimaging Initiative. (2013). White matter abnormalities and structural hippocampal disconnections in amnestic mild cognitive impairment and alzheimer’s disease. PloS One, 8(9), e74776. 10.1371/journal.pone.0074776 Link to item
    • Soucy, J. P., Bartha, R., Bocti, C., Borrie, M., Burhan, A. M., Laforce, R., & Rosa-Neto, P. (2013). Clinical applications of neuroimaging in patients with alzheimer’s disease: A review from the fourth canadian consensus conference on the diagnosis and treatment of dementia 2012. Alzheimer’s Research & Therapy, 5(Suppl 1), S3. 10.1186/alzrt199 Link to item
    • Zhao, L., Boucher, M., Rosa-Neto, P., & Evans, A. C. (2013). Impact of scale space search on age- and gender-related changes in MRI-based cortical morphometry. Human Brain Mapping, 34(9), 2113-2128. 10.1002/hbm.22050 Link to item
    • Elmenhorst, D., Aliaga, A., Bauer, A., & Rosa-Neto, P. (2012). Test-retest stability of cerebral mGluR(5) quantification using [(1)(1)C]ABP688 and positron emission tomography in rats. Synapse (New York, N.Y.), 66(6), 552-560. 10.1002/syn.21542 Link to item
    • Gauthier, S., Patterson, C., Chertkow, H., Gordon, M., Herrmann, N., Rockwood, K., . . . Soucy, J. P. (2012). Recommendations of the 4th canadian consensus conference on the diagnosis and treatment of dementia (CCCDTD4). Canadian Geriatrics Journal : CGJ, 15(4), 120-126. 10.5770/cgj.15.49 Link to item
    • Gauthier, S., Patterson, C., Chertkow, H., Gordon, M., Herrmann, N., Rockwood, K., . . . CCCDTD4 participants. (2012). 4th canadian consensus conference on the diagnosis and treatment of dementia. The Canadian Journal of Neurological Sciences.Le Journal Canadien Des Sciences Neurologiques, 39(6 Suppl 5), S1-8. T267211753311587 Link to item
    • Gauthier, S., Wu, L., Rosa-Neto, P., & Jia, J. (2012). Prevention strategies for alzheimer’s disease. Translational Neurodegeneration, 1(1), 13-9158-1-13. 10.1186/2047-9158-1-13 Link to item
    • Kovacevic, T., Skelin, I., Minuzzi, L., Rosa-Neto, P., & Diksic, M. (2012). Reduced metabotropic glutamate receptor 5 in the flinders sensitive line of rats, an animal model of depression: An autoradiographic study. Brain Research Bulletin, 87(4-5), 406-412. 10.1016/j.brainresbull.2012.01.010 Link to item
    • Parent, M., Bedard, M. A., Aliaga, A., Soucy, J. P., Landry St-Pierre, E., Cyr, M., . . . Rosa-Neto, P. (2012). PET imaging of cholinergic deficits in rats using [18F]fluoroethoxybenzovesamicol ([18F]FEOBV). Neuroimage, 62(1), 555-561. 10.1016/j.neuroimage.2012.04.032 Link to item
    • Tong, X. K., Lecrux, C., Rosa-Neto, P., & Hamel, E. (2012). Age-dependent rescue by simvastatin of alzheimer’s disease cerebrovascular and memory deficits. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 32(14), 4705-4715. 10.1523/JNEUROSCI.0169-12.2012 Link to item
    • Wu, L., Rosa-Neto, P., Hsiung, G. Y., Sadovnick, A. D., Masellis, M., Black, S. E., . . . Gauthier, S. (2012). Early-onset familial alzheimer’s disease (EOFAD). The Canadian Journal of Neurological Sciences.Le Journal Canadien Des Sciences Neurologiques, 39(4), 436-445. W4438L6488727555 Link to item
    • Wu, L., Rowley, J., Mohades, S., Leuzy, A., Dauar, M. T., Shin, M., . . . Alzheimer’s Disease Neuroimaging Initiative. (2012). Dissociation between brain amyloid deposition and metabolism in early mild cognitive impairment. PloS One, 7(10), e47905. 10.1371/journal.pone.0047905 Link to item
    • Berney, A., Leyton, M., Gravel, P., Sibon, I., Sookman, D., Rosa Neto, P., . . . Benkelfat, C. (2011). Brain regional alpha-[11C]methyl-L-tryptophan trapping in medication-free patients with obsessive-compulsive disorder. Archives of General Psychiatry, 68(7), 732-741. 10.1001/archgenpsychiatry.2011.16 Link to item
    • Chen, Z. J., He, Y., Rosa-Neto, P., Gong, G., & Evans, A. C. (2011). Age-related alterations in the modular organization of structural cortical network by using cortical thickness from MRI. Neuroimage, 56(1), 235-245. 10.1016/j.neuroimage.2011.01.010 Link to item
    • Nicolakakis, N., Aboulkassim, T., Aliaga, A., Tong, X. K., Rosa-Neto, P., & Hamel, E. (2011). Intact memory in TGF-beta1 transgenic mice featuring chronic cerebrovascular deficit: Recovery with pioglitazone. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism, 31(1), 200-211. 10.1038/jcbfm.2010.78 Link to item
    • Oishi, K., Huang, H., Yoshioka, T., Ying, S. H., Zee, D. S., Zilles, K., . . . Mori, S. (2011). Superficially located white matter structures commonly seen in the human and the macaque brain with diffusion tensor imaging. Brain Connectivity, 1(1), 37-47. 10.1089/brain.2011.0005 Link to item
    • Wu, L., Rosa-Neto, P., & Gauthier, S. (2011). Use of biomarkers in clinical trials of alzheimer disease: From concept to application. Molecular Diagnosis & Therapy, 15(6), 313-325. 10.2165/11595090-000000000-00000 Link to item
    • Bellec, P., Rosa-Neto, P., Lyttelton, O. C., Benali, H., & Evans, A. C. (2010). Multi-level bootstrap analysis of stable clusters in resting-state fMRI. Neuroimage, 51(3), 1126-1139. 10.1016/j.neuroimage.2010.02.082 Link to item
    • Bertomeu, T., Zvereff, V., Ibrahim, A., Zehntner, S. P., Aliaga, A., Rosa-Neto, P., . . . Gourdeau, H. (2010). TLN-4601 peripheral benzodiazepine receptor (PBR/TSPO) binding properties do not mediate apoptosis but confer tumor-specific accumulation. Biochemical Pharmacology, 80(10), 1572-1579. 10.1016/j.bcp.2010.07.018 Link to item
    • Elmenhorst, D., Minuzzi, L., Aliaga, A., Rowley, J., Massarweh, G., Diksic, M., . . . Rosa-Neto, P. (2010). In vivo and in vitro validation of reference tissue models for the mGluR(5) ligand [(11)C]ABP688. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism, 30(8), 1538-1549. 10.1038/jcbfm.2010.65 Link to item
    • la Fougere, C., Boning, G., Bartmann, H., Wangler, B., Nowak, S., Just, T., . . . Cumming, P. (2010). Uptake and binding of the serotonin 5-HT1A antagonist [18F]-MPPF in brain of rats: Effects of the novel P-glycoprotein inhibitor tariquidar. Neuroimage, 49(2), 1406-1415. 10.1016/j.neuroimage.2009.09.048 Link to item
    • Ongali, B., Nicolakakis, N., Lecrux, C., Aboulkassim, T., Rosa-Neto, P., Papadopoulos, P., . . . Hamel, E. (2010). Transgenic mice overexpressing APP and transforming growth factor-beta1 feature cognitive and vascular hallmarks of alzheimer’s disease. The American Journal of Pathology, 177(6), 3071-3080. 10.2353/ajpath.2010.100339 Link to item
    • Verhaeghe, J., Gravel, P., Mio, R., Fukasawa, R., Rosa-Neto, P., Soucy, J. P., . . . Reader, A. J. (2010). Motion compensation for fully 4D PET reconstruction using PET superset data. Physics in Medicine and Biology, 55(14), 4063-4082. 10.1088/0031-9155/55/14/008 Link to item
    • Zhang, Y., Zhang, J., Oishi, K., Faria, A. V., Jiang, H., Li, X., . . . Mori, S. (2010). Atlas-guided tract reconstruction for automated and comprehensive examination of the white matter anatomy. Neuroimage, 52(4), 1289-1301. 10.1016/j.neuroimage.2010.05.049 Link to item
    • Aznavour, N., Benkelfat, C., Gravel, P., Aliaga, A., Rosa-Neto, P., Bedell, B., . . . Descarries, L. (2009). MicroPET imaging of 5-HT 1A receptors in rat brain: A test-retest [18F]MPPF study. European Journal of Nuclear Medicine and Molecular Imaging, 36(1), 53-62. 10.1007/s00259-008-0891-1 Link to item
    • Chakravarty, M. M., Broadbent, S., Rosa-Neto, P., Lambert, C. M., & Collins, D. L. (2009). Design, construction, and validation of an MRI-compatible vibrotactile stimulator intended for clinical use. Journal of Neuroscience Methods, 184(1), 129-135. 10.1016/j.jneumeth.2009.07.018 Link to item
    • Chakravarty, M. M., Rosa-Neto, P., Broadbent, S., Evans, A. C., & Collins, D. L. (2009). Robust S1, S2, and thalamic activations in individual subjects with vibrotactile stimulation at 1.5 and 3.0 T. Human Brain Mapping, 30(4), 1328-1337. 10.1002/hbm.20598 Link to item
    • Gong, G., Rosa-Neto, P., Carbonell, F., Chen, Z. J., He, Y., & Evans, A. C. (2009). Age- and gender-related differences in the cortical anatomical network. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 29(50), 15684-15693. 10.1523/JNEUROSCI.2308-09.2009 Link to item
    • Massarweh, G., Kovacevic, M., Rosa-Neto, P., Evans, A. C., Diksic, M., & Schirrmacher, R. (2009). Time-efficient and convenient synthesis of [(18)F]altanserin for human PET imaging by a new work-up procedure. Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for use in Agriculture, Industry and Medicine, 67(11), 2040-2043. 10.1016/j.apradiso.2009.07.020 Link to item
    • Oishi, K., Faria, A., Jiang, H., Li, X., Akhter, K., Zhang, J., . . . Mori, S. (2009). Atlas-based whole brain white matter analysis using large deformation diffeomorphic metric mapping: Application to normal elderly and alzheimer’s disease participants. Neuroimage, 46(2), 486-499. Link to item
    • Rosa-Neto, P., Wangler, B., Iovkova, L., Boening, G., Reader, A., Jurkschat, K., & Schirrmacher, E. (2009). 18F]SiFA-isothiocyanate: A new highly effective radioactive labeling agent for lysine-containing proteins. Chembiochem : A European Journal of Chemical Biology, 10(8), 1321-1324. 10.1002/cbic.200900132 Link to item
    • Chen, Z. J., He, Y., Rosa-Neto, P., Germann, J., & Evans, A. C. (2008). Revealing modular architecture of human brain structural networks by using cortical thickness from MRI. Cerebral Cortex (New York, N.Y.: 1991), 18(10), 2374-2381. 10.1093/cercor/bhn003 Link to item
    • Frey, B. N., Rosa-Neto, P., Lubarsky, S., & Diksic, M. (2008). Correlation between serotonin synthesis and 5-HT1A receptor binding in the living human brain: A combined alpha-[11C]MT and [18F]MPPF positron emission tomography study. Neuroimage, 42(2), 850-857. 10.1016/j.neuroimage.2008.05.009 Link to item
    • Nicolakakis, N., Aboulkassim, T., Ongali, B., Lecrux, C., Fernandes, P., Rosa-Neto, P., . . . Hamel, E. (2008). Complete rescue of cerebrovascular function in aged alzheimer’s disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor gamma agonist. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 28(37), 9287-9296. 10.1523/JNEUROSCI.3348-08.2008 Link to item
    • Oishi, K., Zilles, K., Amunts, K., Faria, A., Jiang, H., Li, X., . . . Mori, S. (2008). Human brain white matter atlas: Identification and assignment of common anatomical structures in superficial white matter. Neuroimage, 43(3), 447-457. 10.1016/j.neuroimage.2008.07.009 Link to item
    • Pedersen, K., Simonsen, M., Ostergaard, S. D., Munk, O. L., Rosa-Neto, P., Olsen, A. K., . . . Cumming, P. (2007). Mapping the amphetamine-evoked changes in [11C]raclopride binding in living rat using small animal PET: Modulation by MAO-inhibition. Neuroimage, 35(1), 38-46. S1053-8119(06)01103-7 Link to item
    • Rosa-Neto, P., Benkelfat, C., Sakai, Y., Leyton, M., Morais, J. A., & Diksic, M. (2007). Brain regional alpha-[11C]methyl-L-tryptophan trapping, used as an index of 5-HT synthesis, in healthy adults: Absence of an age effect. European Journal of Nuclear Medicine and Molecular Imaging, 34(8), 1254-1264. 10.1007/s00259-007-0365-x Link to item
    • Doudet, D. J., Rosa-Neto, P., Munk, O. L., Ruth, T. J., Jivan, S., & Cumming, P. (2006). Effect of age on markers for monoaminergic neurons of normal and MPTP-lesioned rhesus monkeys: A multi-tracer PET study. Neuroimage, 30(1), 26-35. S1053-8119(05)00697-X Link to item
    • Leyton, M., Paquette, V., Gravel, P., Rosa-Neto, P., Weston, F., Diksic, M., & Benkelfat, C. (2006). Alpha-[11C]methyl-L-tryptophan trapping in the orbital and ventral medial prefrontal cortex of suicide attempters. European Neuropsychopharmacology : The Journal of the European College of Neuropsychopharmacology, 16(3), 220-223. S0924-977X(05)00143-4 Link to item
    • Gjedde, A., Wong, D. F., Rosa-Neto, P., & Cumming, P. (2005). Mapping neuroreceptors at work: On the definition and interpretation of binding potentials after 20 years of progress. International Review of Neurobiology, 63, 1-20. S0074774205630012 Link to item
    • Rosa-Neto, P., Diksic, M., Leyton, M., Mzengeza, S., & Benkelfat, C. (2005). Stability of alpha-[11C]methyl-L-tryptophan brain trapping in healthy male volunteers. European Journal of Nuclear Medicine and Molecular Imaging, 32(10), 1199-1204. 10.1007/s00259-005-1829-5 Link to item
    • Rosa-Neto, P., Lou, H. C., Cumming, P., Pryds, O., Karrebaek, H., Lunding, J., & Gjedde, A. (2005). Methylphenidate-evoked changes in striatal dopamine correlate with inattention and impulsivity in adolescents with attention deficit hyperactivity disorder. Neuroimage, 25(3), 868-876. S1053-8119(04)00714-1 Link to item
    • Rosa-Neto, P., Diksic, M., Okazawa, H., Leyton, M., Ghadirian, N., Mzengeza, S., . . . Benkelfat, C. (2004). Measurement of brain regional alpha-[11C]methyl-L-tryptophan trapping as a measure of serotonin synthesis in medication-free patients with major depression. Archives of General Psychiatry, 61(6), 556-563. 10.1001/archpsyc.61.6.556 Link to item
    • Rosa-Neto, P., Doudet, D. J., & Cumming, P. (2004). Gradients of dopamine D1- and D2/3-binding sites in the basal ganglia of pig and monkey measured by PET. Neuroimage, 22(3), 1076-1083. 10.1016/j.neuroimage.2004.03.004 Link to item
    • Rosa-Neto, P., Gjedde, A., Olsen, A. K., Jensen, S. B., Munk, O. L., Watanabe, H., & Cumming, P. (2004). MDMA-evoked changes in [11C]raclopride and [11C]NMSP binding in living pig brain. Synapse (New York, N.Y.), 53(4), 222-233. 10.1002/syn.20053 Link to item
    • Rosa-Neto, P., Olsen, A. K., Gjedde, A., Watanabe, H., & Cumming, P. (2004). MDMA-evoked changes in cerebral blood flow in living porcine brain: Correlation with hyperthermia. Synapse (New York, N.Y.), 53(4), 214-221. 10.1002/syn.20052 Link to item
    • Cumming, P., Rosa-Neto, P., Watanabe, H., Smith, D., Bender, D., Clarke, P. B., & Gjedde, A. (2003). Effects of acute nicotine on hemodynamics and binding of [11C]raclopride to dopamine D2,3 receptors in pig brain. Neuroimage, 19(3), 1127-1136. S105381190300079X Link to item
    • Rosa Neto, P., Lou, H., Cumming, P., Pryds, O., & Gjedde, A. (2002). Methylphenidate-evoked potentiation of extracellular dopamine in the brain of adolescents with premature birth: Correlation with attentional deficit. Annals of the New York Academy of Sciences, 965, 434-439. Link to item
    • Bernasconi, A., Martinez, V., Rosa-Neto, P., D’Agostino, D., Bernasconi, N., Berkovic, S., . . . Andermann, F. (2001). Surgical resection for intractable epilepsy in “double cortex” syndrome yields inadequate results. Epilepsia, 42(9), 1124-1129. 39900 Link to item
    • Lopes-Cendes, I., Teive, H. G., Calcagnotto, M. E., Da Costa, J. C., Cardoso, F., Viana, E., . . . Rouleau, G. A. (1997). Frequency of the different mutations causing spinocerebellar ataxia (SCA1, SCA2, MJD/SCA3 and DRPLA) in a large group of brazilian patients. Arquivos De Neuro-Psiquiatria, 55(3B), 519-529. Link to item

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