Cross-frequency coupling between neural oscillations is a phenomenon observed across spatial scales in a wide range of preparations, including human non-invasive electrophysiology. Although the functional role and mechanisms involved are not entirely understood, the concept of interdependent neural oscillations drives an active field of research to comprehend the ubiquitous polyrhythmic activity of the brain, beyond empirical observations. Phase-amplitude coupling, a particular form of cross-frequency coupling between bursts of high-frequency oscillations and the phase of lower frequency rhythms, has recently received considerable attention. However, the measurement methods have relatively poor sensitivity and require long segments of experimental data. This obliterates the resolution of fast changes in coupling related to behavior, and more generally, to the non-stationary dynamics of brain electrophysiology.
This is a companion discussion topic for the original entry at https://open.bic.mni.mcgill.ca/dataset/time-resolved-phase