Amir Shmuel - profile revision

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Dr. Shmuel’s research focuses on two goals. One goal is to understand the neuronal mechanisms that underlie functional brain imaging signals and to evaluate the degree to which these signals reflect the locally measured neuronal activity. The second goal is to elucidate the principles and processes used by the cerebral cortex to analyze visual information and to create coherent visual perception. Employing an integrative approach, Dr. Shmuel’s laboratory uses a combination of imaging and electrical recording techniques: functional Magnetic Resonance Imaging (fMRI), optical imaging using intrinsic signals and voltage-sensitive dyes, multi-channel neurophysiological recordings, and neurophysiology simultaneously with fMRI. Together, these techniques encompass multiple levels of spatial and temporal resolution. Brain activity signals obtained by large-scale non-invasive imaging methods are compared to the activity of ensembles of neurons imaged optically, as well as to electrically recorded activity obtained from groups of neurons and single neurons.

Selected Publications:

    • Chaimow, D., Ugurbil, K., & Shmuel, A. (2018). Optimization of functional MRI for detection, decoding and high-resolution imaging of the response patterns of cortical columns. Neuroimage, 164, 67-99. S1053-8119(17)30300-2 Link to item
    • Chaimow, D., Yacoub, E., Ugurbil, K., & Shmuel, A. (2018). Spatial specificity of the functional MRI blood oxygenation response relative to neuronal activity. Neuroimage, 164, 32-47. S1053-8119(17)30724-3 Link to item
    • Lecrux, C., Sandoe, C. H., Neupane, S., Kropf, P., Toussay, X., Tong, X. K., . . . Hamel, E. (2017). Impact of altered cholinergic tones on the neurovascular coupling response to whisker stimulation. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 37(6), 1518-1531. 10.1523/JNEUROSCI.1784-16.2016 Link to item
    • Dawson, D. A., Lam, J., Lewis, L. B., Carbonell, F., Mendola, J. D., & Shmuel, A. (2016). Partial correlation-based retinotopically organized resting-state functional connectivity within and between areas of the visual cortex reflects more than cortical distance. Brain Connectivity, 6(1), 57-75. 10.1089/brain.2014.0331 Link to item
    • Kropf, P., & Shmuel, A. (2016). 1D current source density (CSD) estimation in inverse theory: A unified framework for higher-order spectral regularization of quadrature and expansion-type CSD methods. Neural Computation, 28(7), 1305-1355. 10.1162/NECO_a_00846 Link to item
    • Tam, A., Dansereau, C., Badhwar, A., Orban, P., Belleville, S., Chertkow, H., . . . Alzheimers Disease Neuroimaging Initiative. (2016). A dataset of multiresolution functional brain parcellations in an elderly population with no or mild cognitive impairment. Data in Brief, 9, 1122-1129. 10.1016/j.dib.2016.11.036 Link to item
    • Sotero, R. C., Bortel, A., Naaman, S., Mocanu, V. M., Kropf, P., Villeneuve, M. Y., & Shmuel, A. (2015). Laminar distribution of phase-amplitude coupling of spontaneous current sources and sinks. Frontiers in Neuroscience, 9, 454. 10.3389/fnins.2015.00454 Link to item
    • Tam, A., Dansereau, C., Badhwar, A., Orban, P., Belleville, S., Chertkow, H., . . . Alzheimer’s Disease Neuroimaging Initiative. (2015). Common effects of amnestic mild cognitive impairment on resting-state connectivity across four independent studies. Frontiers in Aging Neuroscience, 7, 242. 10.3389/fnagi.2015.00242 Link to item
    • Buxton, R. B., Griffeth, V. E., Simon, A. B., Moradi, F., & Shmuel, A. (2014). Variability of the coupling of blood flow and oxygen metabolism responses in the brain: A problem for interpreting BOLD studies but potentially a new window on the underlying neural activity. Frontiers in Neuroscience, 8, 139. 10.3389/fnins.2014.00139 Link to item
    • Carbonell, F., Bellec, P., & Shmuel, A. (2014). Quantification of the impact of a confounding variable on functional connectivity confirms anti-correlated networks in the resting-state. Neuroimage, 86, 343-353. 10.1016/j.neuroimage.2013.10.013 Link to item
    • Sabouni, A., Pouliot, P., Shmuel, A., & Lesage, F. (2014). BRAIN initiative: Fast and parallel solver for real-time monitoring of the eddy current in the brain for TMS applications. Conference Proceedings : …Annual International Conference of the IEEE Engineering in Medicine and Biology Society.IEEE Engineering in Medicine and Biology Society.Annual Conference, 2014, 6250-6253. 10.1109/EMBC.2014.6945057 Link to item
    • Wu, L., Soder, R. B., Schoemaker, D., Carbonnell, F., Sziklas, V., Rowley, J., . . . Rosa-Neto, P. (2014). Resting state executive control network adaptations in amnestic mild cognitive impairment. Journal of Alzheimer’s Disease : JAD, 40(4), 993-1004. 10.3233/JAD-131574 Link to item
    • Dawson, D. A., Cha, K., Lewis, L. B., Mendola, J. D., & Shmuel, A. (2013). Evaluation and calibration of functional network modeling methods based on known anatomical connections. Neuroimage, 67, 331-343. 10.1016/j.neuroimage.2012.11.006 Link to item
    • Leontiev, O., Buracas, G. T., Liang, C., Ances, B. M., Perthen, J. E., Shmuel, A., & Buxton, R. B. (2013). Coupling of cerebral blood flow and oxygen metabolism is conserved for chromatic and luminance stimuli in human visual cortex. Neuroimage, 68, 221-228. 10.1016/j.neuroimage.2012.11.050 Link to item
    • Rowley, J., Fonov, V., Wu, O., Eskildsen, S. F., Schoemaker, D., Wu, L., . . . Alzheimer’s Disease Neuroimaging Initiative. (2013). White matter abnormalities and structural hippocampal disconnections in amnestic mild cognitive impairment and alzheimer’s disease. PloS One, 8(9), e74776. 10.1371/journal.pone.0074776 Link to item
    • Sotero, R. C., & Shmuel, A. (2012). Energy-based stochastic control of neural mass models suggests time-varying effective connectivity in the resting state. Journal of Computational Neuroscience, 32(3), 563-576. 10.1007/s10827-011-0370-8 Link to item
    • Carbonell, F., Bellec, P., & Shmuel, A. (2011). Global and system-specific resting-state fMRI fluctuations are uncorrelated: Principal component analysis reveals anti-correlated networks. Brain Connectivity, 1(6), 496-510. 10.1089/brain.2011.0065 Link to item
    • Chaimow, D., Yacoub, E., Ugurbil, K., & Shmuel, A. (2011). Modeling and analysis of mechanisms underlying fMRI-based decoding of information conveyed in cortical columns. Neuroimage, 56(2), 627-642. 10.1016/j.neuroimage.2010.09.037 Link to item
    • Lecrux, C., Toussay, X., Kocharyan, A., Fernandes, P., Neupane, S., Levesque, M., . . . Hamel, E. (2011). Pyramidal neurons are “neurogenic hubs” in the neurovascular coupling response to whisker stimulation. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 31(27), 9836-9847. 10.1523/JNEUROSCI.4943-10.2011 Link to item
    • Zimmermann, J., Goebel, R., De Martino, F., van de Moortele, P. F., Feinberg, D., Adriany, G., . . . Yacoub, E. (2011). Mapping the organization of axis of motion selective features in human area MT using high-field fMRI. PloS One, 6(12), e28716. 10.1371/journal.pone.0028716 Link to item
    • Shmuel, A., Chaimow, D., Raddatz, G., Ugurbil, K., & Yacoub, E. (2010). Mechanisms underlying decoding at 7 T: Ocular dominance columns, broad structures, and macroscopic blood vessels in V1 convey information on the stimulated eye. Neuroimage, 49(3), 1957-1964. 10.1016/j.neuroimage.2009.08.040 Link to item
    • Sotero, R. C., Bortel, A., Martinez-Cancino, R., Neupane, S., O’Connor, P., Carbonell, F., & Shmuel, A. (2010). Anatomically-constrained effective connectivity among layers in a cortical column modeled and estimated from local field potentials. Journal of Integrative Neuroscience, 9(4), 355-379. S0219635210002548 Link to item
    • Shmuel, A., & Leopold, D. A. (2008). Neuronal correlates of spontaneous fluctuations in fMRI signals in monkey visual cortex: Implications for functional connectivity at rest. Human Brain Mapping, 29(7), 751-761. 10.1002/hbm.20580 Link to item
    • Keliris, G. A., Shmuel, A., Ku, S. P., Pfeuffer, J., Oeltermann, A., Steudel, T., & Logothetis, N. K. (2007). Robust controlled functional MRI in alert monkeys at high magnetic field: Effects of jaw and body movements. Neuroimage, 36(3), 550-570. S1053-8119(07)00171-1 Link to item
    • Pfeuffer, J., Shmuel, A., Keliris, G. A., Steudel, T., Merkle, H., & Logothetis, N. K. (2007). Functional MR imaging in the awake monkey: Effects of motion on dynamic off-resonance and processing strategies. Magnetic Resonance Imaging, 25(6), 869-882. S0730-725X(07)00219-6 Link to item
    • Shmuel, A., Yacoub, E., Chaimow, D., Logothetis, N. K., & Ugurbil, K. (2007). Spatio-temporal point-spread function of fMRI signal in human gray matter at 7 tesla. Neuroimage, 35(2), 539-552. S1053-8119(06)01244-4 Link to item
    • Yacoub, E., Shmuel, A., Logothetis, N., & Ugurbil, K. (2007). Robust detection of ocular dominance columns in humans using hahn spin echo BOLD functional MRI at 7 tesla. Neuroimage, 37(4), 1161-1177. S1053-8119(07)00461-2 Link to item
    • Shmuel, A., Augath, M., Oeltermann, A., & Logothetis, N. K. (2006). Negative functional MRI response correlates with decreases in neuronal activity in monkey visual area V1. Nature Neuroscience, 9(4), 569-577. nn1675 Link to item
    • Shmuel, A., Korman, M., Sterkin, A., Harel, M., Ullman, S., Malach, R., & Grinvald, A. (2005). Retinotopic axis specificity and selective clustering of feedback projections from V2 to V1 in the owl monkey. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 25(8), 2117-2131. 25/8/2117 Link to item
    • Yacoub, E., Van De Moortele, P. F., Shmuel, A., & Ugurbil, K. (2005). Signal and noise characteristics of hahn SE and GE BOLD fMRI at 7 T in humans. Neuroimage, 24(3), 738-750. S1053-8119(04)00516-6 Link to item
    • Swindale, N. V., Grinvald, A., & Shmuel, A. (2003). The spatial pattern of response magnitude and selectivity for orientation and direction in cat visual cortex. Cerebral Cortex (New York, N.Y.: 1991), 13(3), 225-238. Link to item
    • Pfeuffer, J., Adriany, G., Shmuel, A., Yacoub, E., Van De Moortele, P. F., Hu, X., & Ugurbil, K. (2002). Perfusion-based high-resolution functional imaging in the human brain at 7 tesla. Magnetic Resonance in Medicine, 47(5), 903-911. 10.1002/mrm.10154 Link to item
    • Pfeuffer, J., van de Moortele, P. F., Yacoub, E., Shmuel, A., Adriany, G., Andersen, P., . . . Hu, X. (2002). Zoomed functional imaging in the human brain at 7 tesla with simultaneous high spatial and high temporal resolution. Neuroimage, 17(1), 272-286. S1053811902911031 Link to item
    • Shmuel, A., Yacoub, E., Pfeuffer, J., Van de Moortele, P. F., Adriany, G., Hu, X., & Ugurbil, K. (2002). Sustained negative BOLD, blood flow and oxygen consumption response and its coupling to the positive response in the human brain. Neuron, 36(6), 1195-1210. S0896627302010619 Link to item
    • Yacoub, E., Shmuel, A., Pfeuffer, J., Van De Moortele, P. F., Adriany, G., Andersen, P., . . . Hu, X. (2001). Imaging brain function in humans at 7 tesla. Magnetic Resonance in Medicine, 45(4), 588-594. 10.1002/mrm.1080 Link to item
    • Yacoub, E., Shmuel, A., Pfeuffer, J., Van De Moortele, P. F., Adriany, G., Ugurbil, K., & Hu, X. (2001). Investigation of the initial dip in fMRI at 7 tesla. NMR in Biomedicine, 14(7-8), 408-412. 10.1002/nbm.715 Link to item
    • Shmuel, A., & Grinvald, A. (2000). Coexistence of linear zones and pinwheels within orientation maps in cat visual cortex. Proceedings of the National Academy of Sciences of the United States of America, 97(10), 5568-5573. 97/10/5568 Link to item
    • Shmuel, A., & Grinvald, A. (1996). Functional organization for direction of motion and its relationship to orientation maps in cat area 18. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 16(21), 6945-6964. Link to item

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