Alain Dagher - profile revision

Dr. Alain Dagher is a neurologist specializing in movement disorders and functional brain imaging. His research aims at understanding the function of the basal ganglia, with a particular emphasis on appetitive behaviours. This involves studying how we learn about rewards and punishments, and become motivated to engage in reward-seeking behaviour. The two main techniques used are positron emission tomography (PET) targeting the dopamine system, and functional magnetic resonance imaging (fMRI). The research focusses on Parkinson’s Disease, stress, drug addiction (notably cigarette smoking), pathological gambling, and obesity. Dr. Dagher is funded by CIHR, FRSQ, NIDA, the Parkinson Society of Canada, the Institute for Research on Pathological Gambling and Related Disorders, and Unilever PLC.

Selected Publications:

  • Han, J. E., Boachie, N., Garcia-Garcia, I., Michaud, A., & Dagher, A. (2018). Neural correlates of dietary self-control in healthy adults: A meta-analysis of functional brain imaging studies. Physiology & Behavior, S0031-9384(18)30098-2 Link to item
  • Parada, M., Gerard, M., Larcher, K., Dagher, A., & Binik, Y. M. (2018). How hot are they? neural correlates of genital arousal: An infrared thermographic and functional magnetic resonance imaging study of sexual arousal in men and women. The Journal of Sexual Medicine, 15(2), 217-229. S1743-6095(17)31880-5 Link to item
  • Ramdani, C., Vidal, F., Dagher, A., Carbonnell, L., & Hasbroucq, T. (2018). Dopamine and response selection: An acute Phenylalanine/Tyrosine depletion study. Psychopharmacology, 10.1007/s00213-018-4846-3 Link to item
  • Shakra, M. A., Leyton, M., Moghnieh, H., Pruessner, J., Dagher, A., & Pihl, R. (2018). Neurobiological correlates and predictors of two distinct personality trait pathways to escalated alcohol use. Ebiomedicine, 27, 86-93. S2352-3964(17)30468-1 Link to item
  • Cherkasova, M. V., Faridi, N., Casey, K. F., Larcher, K., O’Driscoll, G. A., Hechtman, L., . . . Leyton, M. (2017). Differential associations between cortical thickness and striatal dopamine in treatment-naive adults with ADHD vs. healthy controls. Frontiers in Human Neuroscience, 11, 421. 10.3389/fnhum.2017.00421 Link to item
  • Cox, S. M. L., Yau, Y., Larcher, K., Durand, F., Kolivakis, T., Delaney, J. S., . . . Leyton, M. (2017). Cocaine cue-induced dopamine release in recreational cocaine users. Scientific Reports, 7, 46665. 10.1038/srep46665 Link to item
  • Dagher, A. (2017). Retuning brain circuitry to treat mental illness: The role of functional neuroimaging. commentary for the special issue: Mechanisms of change. Neuroimage, 151, 128-129. S1053-8119(17)30026-5 Link to item
  • Dagher, A., & Misic, B. (2017). Holding onto youth. Cell Metabolism, 26(2), 284-285. S1550-4131(17)30437-0 Link to item
  • Dalle Molle, R., Fatemi, H., Dagher, A., Levitan, R. D., Silveira, P. P., & Dube, L. (2017). Gene and environment interaction: Is the differential susceptibility hypothesis relevant for obesity? Neuroscience and Biobehavioral Reviews, 73, 326-339. S0149-7634(16)30328-1 Link to item
  • Das, S., Glatard, T., Rogers, C., Saigle, J., Paiva, S., MacIntyre, L., . . . Evans, A. C. (2017). Cyberinfrastructure for open science at the montreal neurological institute. Frontiers in Neuroinformatics, 10, 53. 10.3389/fninf.2016.00053 Link to item
  • Fereshtehnejad, S. M., Zeighami, Y., Dagher, A., & Postuma, R. B. (2017). Clinical criteria for subtyping parkinson’s disease: Biomarkers and longitudinal progression. Brain : A Journal of Neurology, 140(7), 1959-1976. 10.1093/brain/awx118 Link to item
  • Garcia-Garcia, I., Zeighami, Y., & Dagher, A. (2017). Reward prediction errors in drug addiction and parkinson’s disease: From neurophysiology to neuroimaging. Current Neurology and Neuroscience Reports, 17(6), 46-017-0755-9. 10.1007/s11910-017-0755-9 Link to item
  • Guimaraes, R. P., Arci Santos, M. C., Dagher, A., Campos, L. S., Azevedo, P., Piovesana, L. G., . . . D’Abreu, A. C. (2017). Pattern of reduced functional connectivity and structural abnormalities in parkinson’s disease: An exploratory study. Frontiers in Neurology, 7, 243. 10.3389/fneur.2016.00243 Link to item
  • Jaworska, N., Cox, S. M., Casey, K. F., Boileau, I., Cherkasova, M., Larcher, K., . . . Leyton, M. (2017). Is there a relation between novelty seeking, striatal dopamine release and frontal cortical thickness? PloS One, 12(3), e0174219. 10.1371/journal.pone.0174219 Link to item
  • Mason, A. E., Vainik, U., Acree, M., Tomiyama, A. J., Dagher, A., Epel, E. S., & Hecht, F. M. (2017). Improving assessment of the spectrum of reward-related eating: The RED-13. Frontiers in Psychology, 8, 795. 10.3389/fpsyg.2017.00795 Link to item
  • Michaud, A., Vainik, U., Garcia-Garcia, I., & Dagher, A. (2017). Overlapping neural endophenotypes in addiction and obesity. Frontiers in Endocrinology, 8, 127. 10.3389/fendo.2017.00127 Link to item
  • Neseliler, S., Han, J. E., & Dagher, A. (2017). The use of functional magnetic resonance imaging in the study of appetite and obesity. In 2nd, & R. B. S. Harris (Eds.), Appetite and food intake: Central control (pp. 117-134). Boca Raton (FL): by Taylor & Francis Group, LLC.10.1201/9781315120171
  • Neseliler, S., Tannenbaum, B., Zacchia, M., Larcher, K., Coulter, K., Lamarche, M., . . . Dagher, A. (2017). Academic stress and personality interact to increase the neural response to high-calorie food cues. Appetite, 116, 306-314. S0195-6663(16)30652-3 Link to item
  • Simioni, A. C., Dagher, A., & Fellows, L. K. (2017). Effects of levodopa on corticostriatal circuits supporting working memory in parkinson’s disease. Cortex; a Journal Devoted to the Study of the Nervous System and Behavior, 93, 193-205. S0010-9452(17)30184-3 Link to item
  • Zeighami, Y., Fereshtehnejad, S. M., Dadar, M., Collins, D. L., Postuma, R. B., Misic, B., & Dagher, A. (2017). A clinical-anatomical signature of parkinson’s disease identified with partial least squares and magnetic resonance imaging. Neuroimage, S1053-8119(17)31074-1 Link to item
  • Zhang, Y., Larcher, K. M., Misic, B., & Dagher, A. (2017). Anatomical and functional organization of the human substantia nigra and its connections. Elife, 6, 10.7554/eLife.26653. 10.7554/eLife.26653 Link to item
  • Bourque, J., Baker, T. E., Dagher, A., Evans, A. C., Garavan, H., Leyton, M., . . . Conrod, P. J. (2016). Effects of delaying binge drinking on adolescent brain development: A longitudinal neuroimaging study. BMC Psychiatry, 16(1), 445-016-1148-3. 10.1201/9781315120171-6 Link to item
  • Leblond, C. S., Webber, A., Gan-Or, Z., Moore, F., Dagher, A., Dion, P. A., & Rouleau, G. A. (2016). De novo FUS P525L mutation in juvenile amyotrophic lateral sclerosis with dysphonia and diplopia. Neurology.Genetics, 2(2), e63. 10.1212/NXG.0000000000000063 Link to item
  • Mackey, S., Kan, K. J., Chaarani, B., Alia-Klein, N., Batalla, A., Brooks, S., . . . Conrod, P. (2016). Genetic imaging consortium for addiction medicine: From neuroimaging to genes. Progress in Brain Research, 224, 203-223. 10.1016/bs.pbr.2015.07.026 Link to item
  • Milella, M. S., Fotros, A., Gravel, P., Casey, K. F., Larcher, K., Verhaeghe, J. A., . . . Leyton, M. (2016). Cocaine cue-induced dopamine release in the human prefrontal cortex. Journal of Psychiatry & Neuroscience : JPN, 41(5), 322-330. 10.1503/jpn.150207 Link to item
  • Parada, M., Gerard, M., Larcher, K., Dagher, A., & Binik, Y. M. (2016). Neural representation of subjective sexual arousal in men and women. The Journal of Sexual Medicine, 13(10), 1508-1522. 10.1016/j.jsxm.2016.08.008 Link to item
  • Tam, A., Dansereau, C., Badhwar, A., Orban, P., Belleville, S., Chertkow, H., . . . Alzheimers Disease Neuroimaging Initiative. (2016). A dataset of multiresolution functional brain parcellations in an elderly population with no or mild cognitive impairment. Data in Brief, 9, 1122-1129. 10.1016/j.dib.2016.11.036 Link to item
  • Bohbot, V. D., Allen, J. J., Dagher, A., Dumoulin, S. O., Evans, A. C., Petrides, M., . . . Nadel, L. (2015). Role of the parahippocampal cortex in memory for the configuration but not the identity of objects: Converging evidence from patients with selective thermal lesions and fMRI. Frontiers in Human Neuroscience, 9, 431. 10.3389/fnhum.2015.00431 Link to item
  • Cox, S. M., Frank, M. J., Larcher, K., Fellows, L. K., Clark, C. A., Leyton, M., & Dagher, A. (2015). Striatal D1 and D2 signaling differentially predict learning from positive and negative outcomes. Neuroimage, 109, 95-101. 10.1016/j.neuroimage.2014.12.070 Link to item
  • Ghosn, M., Dagher, A., & El-Karak, F. (2015). Prostate-specific antigen doubling time and response to cabazitaxel in a hormone-resistant metastatic prostate cancer patient. Journal of Biomedical Research, 29(5), 420-422. 10.7555/JBR.28.20130148 Link to item
  • Ramdani, C., Carbonnell, L., Vidal, F., Beranger, C., Dagher, A., & Hasbroucq, T. (2015). Dopamine precursors depletion impairs impulse control in healthy volunteers. Psychopharmacology, 232(2), 477-487. 10.1007/s00213-014-3686-z Link to item
  • Salimpoor, V. N., Zald, D. H., Zatorre, R. J., Dagher, A., & McIntosh, A. R. (2015). Predictions and the brain: How musical sounds become rewarding. Trends in Cognitive Sciences, 19(2), 86-91. 10.1016/j.tics.2014.12.001 Link to item
  • Sharkey, R. J., Karama, S., & Dagher, A. (2015). Overweight is not associated with cortical thickness alterations in children. Frontiers in Neuroscience, 9, 24. 10.3389/fnins.2015.00024 Link to item
  • Simioni, A. C., Dagher, A., & Fellows, L. K. (2015). Compensatory striatal-cerebellar connectivity in mild-moderate parkinson’s disease. NeuroImage.Clinical, 10, 54-62. 10.1016/j.nicl.2015.11.005 Link to item
  • Tam, A., Dansereau, C., Badhwar, A., Orban, P., Belleville, S., Chertkow, H., . . . Alzheimer’s Disease Neuroimaging Initiative. (2015). Common effects of amnestic mild cognitive impairment on resting-state connectivity across four independent studies. Frontiers in Aging Neuroscience, 7, 242. 10.3389/fnagi.2015.00242 Link to item
  • Vainik, U., Neseliler, S., Konstabel, K., Fellows, L. K., & Dagher, A. (2015). Eating traits questionnaires as a continuum of a single concept. uncontrolled eating. Appetite, 90, 229-239. 10.1016/j.appet.2015.03.004 Link to item
  • Zeighami, Y., Ulla, M., Iturria-Medina, Y., Dadar, M., Zhang, Y., Larcher, K. M., . . . Dagher, A. (2015). Network structure of brain atrophy in de novo parkinson’s disease. Elife, 4, 10.7554/eLife.08440. 10.7554/eLife.08440 Link to item
  • Carbonell, F., Nagano-Saito, A., Leyton, M., Cisek, P., Benkelfat, C., He, Y., & Dagher, A. (2014). Dopamine precursor depletion impairs structure and efficiency of resting state brain functional networks. Neuropharmacology, 84, 90-100. 10.1016/j.neuropharm.2013.12.021 Link to item
  • Casey, K. F., Benkelfat, C., Cherkasova, M. V., Baker, G. B., Dagher, A., & Leyton, M. (2014). Reduced dopamine response to amphetamine in subjects at ultra-high risk for addiction. Biological Psychiatry, 76(1), 23-30. 10.1016/j.biopsych.2013.08.033 Link to item
  • Cherkasova, M. V., Faridi, N., Casey, K. F., O’Driscoll, G. A., Hechtman, L., Joober, R., . . . Benkelfat, C. (2014). Amphetamine-induced dopamine release and neurocognitive function in treatment-naive adults with ADHD. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 39(6), 1498-1507. 10.1038/npp.2013.349 Link to item
  • Clark, C. A., & Dagher, A. (2014). The role of dopamine in risk taking: A specific look at parkinson’s disease and gambling. Frontiers in Behavioral Neuroscience, 8, 196. 10.3389/fnbeh.2014.00196 Link to item
  • Dagher, A. (2014). Alcohol and the paradox of self-control. Biological Psychiatry, 76(9), 674-675. 10.1016/j.biopsych.2014.08.019 Link to item
  • Setiawan, E., Pihl, R. O., Dagher, A., Schlagintweit, H., Casey, K. F., Benkelfat, C., & Leyton, M. (2014). Differential striatal dopamine responses following oral alcohol in individuals at varying risk for dependence. Alcoholism, Clinical and Experimental Research, 38(1), 126-134. 10.1111/acer.12218 Link to item
  • Tang, D. W., Fellows, L. K., & Dagher, A. (2014). Behavioral and neural valuation of foods is driven by implicit knowledge of caloric content. Psychological Science, 25(12), 2168-2176. 10.1177/0956797614552081 Link to item
  • Wu, L., Soder, R. B., Schoemaker, D., Carbonnell, F., Sziklas, V., Rowley, J., . . . Rosa-Neto, P. (2014). Resting state executive control network adaptations in amnestic mild cognitive impairment. Journal of Alzheimer’s Disease : JAD, 40(4), 993-1004. 10.3233/JAD-131574 Link to item
  • Casey, K. F., Cherkasova, M. V., Larcher, K., Evans, A. C., Baker, G. B., Dagher, A., . . . Leyton, M. (2013). Individual differences in frontal cortical thickness correlate with the d-amphetamine-induced striatal dopamine response in humans. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 33(38), 15285-15294. 10.1523/JNEUROSCI.5029-12.2013 Link to item
  • Fotros, A., Casey, K. F., Larcher, K., Verhaeghe, J. A., Cox, S. M., Gravel, P., . . . Leyton, M. (2013). Cocaine cue-induced dopamine release in amygdala and hippocampus: A high-resolution PET [(1)(8)F]fallypride study in cocaine dependent participants. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 38(9), 1780-1788. 10.1038/npp.2013.77 Link to item
  • Hayashi, T., Ko, J. H., Strafella, A. P., & Dagher, A. (2013). Dorsolateral prefrontal and orbitofrontal cortex interactions during self-control of cigarette craving. Proceedings of the National Academy of Sciences of the United States of America, 110(11), 4422-4427. 10.1073/pnas.1212185110 Link to item
  • Nagano-Saito, A., Dagher, A., Booij, L., Gravel, P., Welfeld, K., Casey, K. F., . . . Benkelfat, C. (2013). Stress-induced dopamine release in human medial prefrontal cortex–18F-fallypride/PET study in healthy volunteers. Synapse (New York, N.Y.), 67(12), 821-830. 10.1002/syn.21700 Link to item
  • Rowley, J., Fonov, V., Wu, O., Eskildsen, S. F., Schoemaker, D., Wu, L., . . . Alzheimer’s Disease Neuroimaging Initiative. (2013). White matter abnormalities and structural hippocampal disconnections in amnestic mild cognitive impairment and alzheimer’s disease. PloS One, 8(9), e74776. 10.1371/journal.pone.0074776 Link to item
  • Salimpoor, V. N., van den Bosch, I., Kovacevic, N., McIntosh, A. R., Dagher, A., & Zatorre, R. J. (2013). Interactions between the nucleus accumbens and auditory cortices predict music reward value. Science (New York, N.Y.), 340(6129), 216-219. 10.1126/science.1231059 Link to item
  • Vainik, U., Dagher, A., Dube, L., & Fellows, L. K. (2013). Neurobehavioural correlates of body mass index and eating behaviours in adults: A systematic review. Neuroscience and Biobehavioral Reviews, 37(3), 279-299. 10.1016/j.neubiorev.2012.11.008 Link to item
  • Coull, J. T., Hwang, H. J., Leyton, M., & Dagher, A. (2012). Dopamine precursor depletion impairs timing in healthy volunteers by attenuating activity in putamen and supplementary motor area. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 32(47), 16704-16715. 10.1523/JNEUROSCI.1258-12.2012 Link to item
  • Dagher, A. (2012). Addiction as aberrant learning-evidence from parkinson’s disease. Addiction (Abingdon, England), 107(2), 248-250. 10.1111/j.1360-0443.2011.03624.x Link to item
  • Dagher, A. (2012). Functional brain imaging of appetite. Trends in Endocrinology and Metabolism: TEM, 23(5), 250-260. 10.1016/j.tem.2012.02.009 Link to item
  • Hammond, R. A., Ornstein, J. T., Fellows, L. K., Dube, L., Levitan, R., & Dagher, A. (2012). A model of food reward learning with dynamic reward exposure. Frontiers in Computational Neuroscience, 6, 82. 10.3389/fncom.2012.00082 Link to item
  • Nagano-Saito, A., Cisek, P., Perna, A. S., Shirdel, F. Z., Benkelfat, C., Leyton, M., & Dagher, A. (2012). From anticipation to action, the role of dopamine in perceptual decision making: An fMRI-tyrosine depletion study. Journal of Neurophysiology, 108(2), 501-512. 10.1152/jn.00592.2011 Link to item
  • Simioni, A. C., Dagher, A., & Fellows, L. K. (2012). Dissecting the effects of disease and treatment on impulsivity in parkinson’s disease. Journal of the International Neuropsychological Society : JINS, 18(6), 942-951. 10.1017/S135561771200094X Link to item
  • Tang, D. W., Hello, B., Mroziewicz, M., Fellows, L. K., Tyndale, R. F., & Dagher, A. (2012). Genetic variation in CYP2A6 predicts neural reactivity to smoking cues as measured using fMRI. Neuroimage, 60(4), 2136-2143. 10.1016/j.neuroimage.2012.01.119 Link to item
  • Cox, S. M., Benkelfat, C., Dagher, A., Delaney, J. S., Durand, F., Kolivakis, T., . . . Leyton, M. (2011). Effects of lowered serotonin transmission on cocaine-induced striatal dopamine response: PET [(1)(1)C]raclopride study in humans. The British Journal of Psychiatry : The Journal of Mental Science, 199(5), 391-397. 10.1192/bjp.bp.110.084178 Link to item
  • Engert, V., Efanov, S. I., Dedovic, K., Dagher, A., & Pruessner, J. C. (2011). Increased cortisol awakening response and afternoon/evening cortisol output in healthy young adults with low early life parental care. Psychopharmacology, 214(1), 261-268. 10.1007/s00213-010-1918-4 Link to item
  • Malik, S., McGlone, F., & Dagher, A. (2011). State of expectancy modulates the neural response to visual food stimuli in humans. Appetite, 56(2), 302-309. 10.1016/j.appet.2011.01.005 Link to item
  • Salimpoor, V. N., Benovoy, M., Larcher, K., Dagher, A., & Zatorre, R. J. (2011). Anatomically distinct dopamine release during anticipation and experience of peak emotion to music. Nature Neuroscience, 14(2), 257-262. 10.1038/nn.2726 Link to item
  • Soliman, A., O’Driscoll, G. A., Pruessner, J., Joober, R., Ditto, B., Streicker, E., . . . Dagher, A. (2011). Limbic response to psychosocial stress in schizotypy: A functional magnetic resonance imaging study. Schizophrenia Research, 131(1-3), 184-191. 10.1016/j.schres.2011.05.016 Link to item
  • Stice, E., Yokum, S., Zald, D., & Dagher, A. (2011). Dopamine-based reward circuitry responsivity, genetics, and overeating. Current Topics in Behavioral Neurosciences, 6, 81-93. 10.1007/7854_2010_89 Link to item
  • Allman, A. A., Benkelfat, C., Durand, F., Sibon, I., Dagher, A., Leyton, M., . . . O’Driscoll, G. A. (2010). Effect of D-amphetamine on inhibition and motor planning as a function of baseline performance. Psychopharmacology, 211(4), 423-433. 10.1007/s00213-010-1912-x Link to item
  • Engert, V., Efanov, S. I., Dedovic, K., Duchesne, A., Dagher, A., & Pruessner, J. C. (2010). Perceived early-life maternal care and the cortisol response to repeated psychosocial stress. Journal of Psychiatry & Neuroscience : JPN, 35(6), 370-377. 10.1503/jpn.100022 Link to item
  • Pruessner, J. C., Dedovic, K., Pruessner, M., Lord, C., Buss, C., Collins, L., . . . Lupien, S. J. (2010). Stress regulation in the central nervous system: Evidence from structural and functional neuroimaging studies in human populations - 2008 curt richter award winner. Psychoneuroendocrinology, 35(1), 179-191. 10.1016/j.psyneuen.2009.02.016 Link to item
  • Stice, E., & Dagher, A. (2010). Genetic variation in dopaminergic reward in humans. Forum of Nutrition, 63, 176-185. 10.1159/000264405 Link to item
  • Costes, N., Dagher, A., Larcher, K., Evans, A. C., Collins, D. L., & Reilhac, A. (2009). Motion correction of multi-frame PET data in neuroreceptor mapping: Simulation based validation. Neuroimage, 47(4), 1496-1505. 10.1016/j.neuroimage.2009.05.052 Link to item
  • Cox, S. M., Benkelfat, C., Dagher, A., Delaney, J. S., Durand, F., McKenzie, S. A., . . . Leyton, M. (2009). Striatal dopamine responses to intranasal cocaine self-administration in humans. Biological Psychiatry, 65(10), 846-850. 10.1016/j.biopsych.2009.01.021 Link to item
  • Dagher, A., & Robbins, T. W. (2009). Personality, addiction, dopamine: Insights from parkinson’s disease. Neuron, 61(4), 502-510. 10.1016/j.neuron.2009.01.031 Link to item
  • Dagher, A., Tannenbaum, B., Hayashi, T., Pruessner, J. C., & McBride, D. (2009). An acute psychosocial stress enhances the neural response to smoking cues. Brain Research, 1293, 40-48. 10.1016/j.brainres.2009.07.048 Link to item
  • He, Y., Dagher, A., Chen, Z., Charil, A., Zijdenbos, A., Worsley, K., & Evans, A. (2009). Impaired small-world efficiency in structural cortical networks in multiple sclerosis associated with white matter lesion load. Brain : A Journal of Neurology, 132(Pt 12), 3366-3379. 10.1093/brain/awp089 Link to item
  • Nagano-Saito, A., Liu, J., Doyon, J., & Dagher, A. (2009). Dopamine modulates default mode network deactivation in elderly individuals during the tower of london task. Neuroscience Letters, 458(1), 1-5. 10.1016/j.neulet.2009.04.025 Link to item
  • Fraraccio, M., Ptito, A., Sadikot, A., Panisset, M., & Dagher, A. (2008). Absence of cognitive deficits following deep brain stimulation of the subthalamic nucleus for the treatment of parkinson’s disease. Archives of Clinical Neuropsychology : The Official Journal of the National Academy of Neuropsychologists, 23(4), 399-408. 10.1016/j.acn.2008.02.001 Link to item
  • Hakyemez, H. S., Dagher, A., Smith, S. D., & Zald, D. H. (2008). Striatal dopamine transmission in healthy humans during a passive monetary reward task. Neuroimage, 39(4), 2058-2065. S1053-8119(07)00991-3 Link to item
  • Malik, S., McGlone, F., Bedrossian, D., & Dagher, A. (2008). Ghrelin modulates brain activity in areas that control appetitive behavior. Cell Metabolism, 7(5), 400-409. 10.1016/j.cmet.2008.03.007 Link to item
  • Mendez, I., Vinuela, A., Astradsson, A., Mukhida, K., Hallett, P., Robertson, H., . . . Isacson, O. (2008). Dopamine neurons implanted into people with parkinson’s disease survive without pathology for 14 years. Nature Medicine, 14(5), 507-509. 10.1038/nm1752 Link to item
  • Nagano-Saito, A., Leyton, M., Monchi, O., Goldberg, Y. K., He, Y., & Dagher, A. (2008). Dopamine depletion impairs frontostriatal functional connectivity during a set-shifting task. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 28(14), 3697-3706. 10.1523/JNEUROSCI.3921-07.2008 Link to item
  • Pruessner, J. C., Dedovic, K., Khalili-Mahani, N., Engert, V., Pruessner, M., Buss, C., . . . Lupien, S. (2008). Deactivation of the limbic system during acute psychosocial stress: Evidence from positron emission tomography and functional magnetic resonance imaging studies. Biological Psychiatry, 63(2), 234-240. S0006-3223(07)00435-0 Link to item
  • Soliman, A., O’Driscoll, G. A., Pruessner, J., Holahan, A. L., Boileau, I., Gagnon, D., & Dagher, A. (2008). Stress-induced dopamine release in humans at risk of psychosis: A [11C]raclopride PET study. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 33(8), 2033-2041. 1301597 Link to item
  • Berney, A., Panisset, M., Sadikot, A. F., Ptito, A., Dagher, A., Fraraccio, M., . . . Benkelfat, C. (2007). Mood stability during acute stimulator challenge in parkinson’s disease patients under long-term treatment with subthalamic deep brain stimulation. Movement Disorders : Official Journal of the Movement Disorder Society, 22(8), 1093-1096. 10.1002/mds.21245 Link to item
  • Boileau, I., Dagher, A., Leyton, M., Welfeld, K., Booij, L., Diksic, M., & Benkelfat, C. (2007). Conditioned dopamine release in humans: A positron emission tomography [11C]raclopride study with amphetamine. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 27(15), 3998-4003. 27/15/3998 Link to item
  • Charil, A., Dagher, A., Lerch, J. P., Zijdenbos, A. P., Worsley, K. J., & Evans, A. C. (2007). Focal cortical atrophy in multiple sclerosis: Relation to lesion load and disability. Neuroimage, 34(2), 509-517. S1053-8119(06)01021-4 Link to item
  • Dagher, A. (2007). Shopping centers in the brain. Neuron, 53(1), 7-8. S0896-6273(06)00999-8 Link to item
  • Dagher, A., & Nagano-Saito, A. (2007). Functional and anatomical magnetic resonance imaging in parkinson’s disease. Molecular Imaging and Biology : MIB : The Official Publication of the Academy of Molecular Imaging, 9(4), 234-242. 10.1007/s11307-007-0089-0 Link to item
  • Wood, P. B., Schweinhardt, P., Jaeger, E., Dagher, A., Hakyemez, H., Rabiner, E. A., . . . Chizh, B. A. (2007). Fibromyalgia patients show an abnormal dopamine response to pain. The European Journal of Neuroscience, 25(12), 3576-3582. EJN5623 Link to item
  • Boileau, I., Dagher, A., Leyton, M., Gunn, R. N., Baker, G. B., Diksic, M., & Benkelfat, C. (2006). Modeling sensitization to stimulants in humans: An [11C]raclopride/positron emission tomography study in healthy men. Archives of General Psychiatry, 63(12), 1386-1395. 63/12/1386 Link to item
  • McBride, D., Barrett, S. P., Kelly, J. T., Aw, A., & Dagher, A. (2006). Effects of expectancy and abstinence on the neural response to smoking cues in cigarette smokers: An fMRI study. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 31(12), 2728-2738. 1301075 Link to item
  • Postuma, R. B., & Dagher, A. (2006). Basal ganglia functional connectivity based on a meta-analysis of 126 positron emission tomography and functional magnetic resonance imaging publications. Cerebral Cortex (New York, N.Y.: 1991), 16(10), 1508-1521. bhj088 Link to item
  • Landau, A. M., Luk, K. C., Jones, M. L., Siegrist-Johnstone, R., Young, Y. K., Kouassi, E., . . . Desbarats, J. (2005). Defective fas expression exacerbates neurotoxicity in a model of parkinson’s disease. The Journal of Experimental Medicine, 202(5), 575-581. jem.20050163 Link to item
  • Mendez, I., Sanchez-Pernaute, R., Cooper, O., Vinuela, A., Ferrari, D., Bjorklund, L., . . . Isacson, O. (2005). Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with parkinson’s disease. Brain : A Journal of Neurology, 128(Pt 7), 1498-1510. awh510 Link to item
  • Barrett, S. P., Boileau, I., Okker, J., Pihl, R. O., & Dagher, A. (2004). The hedonic response to cigarette smoking is proportional to dopamine release in the human striatum as measured by positron emission tomography and [11C]raclopride. Synapse (New York, N.Y.), 54(2), 65-71. 10.1002/syn.20066 Link to item
  • Leyton, M., Dagher, A., Boileau, I., Casey, K., Baker, G. B., Diksic, M., . . . Benkelfat, C. (2004). Decreasing amphetamine-induced dopamine release by acute phenylalanine/tyrosine depletion: A PET/[11C]raclopride study in healthy men. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 29(2), 427-432. 10.1038/sj.npp.1300328 Link to item
  • Monchi, O., Petrides, M., Doyon, J., Postuma, R. B., Worsley, K., & Dagher, A. (2004). Neural bases of set-shifting deficits in parkinson’s disease. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 24(3), 702-710. 10.1523/JNEUROSCI.4860-03.2004 Link to item
  • Moro, E., Lang, A. E., Strafella, A. P., Poon, Y. Y., Arango, P. M., Dagher, A., . . . Lozano, A. M. (2004). Bilateral globus pallidus stimulation for huntington’s disease. Annals of Neurology, 56(2), 290-294. 10.1002/ana.20183 Link to item
  • Nagano-Saito, A., Kato, T., Arahata, Y., Washimi, Y., Nakamura, A., Abe, Y., . . . Ito, K. (2004). Cognitive- and motor-related regions in parkinson’s disease: FDOPA and FDG PET studies. Neuroimage, 22(2), 553-561. 10.1016/j.neuroimage.2004.01.030 Link to item
  • Pruessner, J. C., Champagne, F., Meaney, M. J., & Dagher, A. (2004). Dopamine release in response to a psychological stress in humans and its relationship to early life maternal care: A positron emission tomography study using [11C]raclopride. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 24(11), 2825-2831. 10.1523/JNEUROSCI.3422-03.2004 Link to item
  • Xie, G., Gunn, R. N., Dagher, A., Daloze, T., Plourde, G., Backman, S. B., . . . Fiset, P. (2004). PET quantification of muscarinic cholinergic receptors with [N-11C-methyl]-benztropine and application to studies of propofol-induced unconsciousness in healthy human volunteers. Synapse (New York, N.Y.), 51(2), 91-101. 10.1002/syn.10292 Link to item
  • Zald, D. H., Boileau, I., El-Dearedy, W., Gunn, R., McGlone, F., Dichter, G. S., & Dagher, A. (2004). Dopamine transmission in the human striatum during monetary reward tasks. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 24(17), 4105-4112. 10.1523/JNEUROSCI.4643-03.2004 Link to item
  • Boileau, I., Assaad, J. M., Pihl, R. O., Benkelfat, C., Leyton, M., Diksic, M., . . . Dagher, A. (2003). Alcohol promotes dopamine release in the human nucleus accumbens. Synapse (New York, N.Y.), 49(4), 226-231. 10.1002/syn.10226 Link to item
  • Charil, A., Zijdenbos, A. P., Taylor, J., Boelman, C., Worsley, K. J., Evans, A. C., & Dagher, A. (2003). Statistical mapping analysis of lesion location and neurological disability in multiple sclerosis: Application to 452 patient data sets. Neuroimage, 19(3), 532-544. S1053811903001174 Link to item
  • Iaria, G., Petrides, M., Dagher, A., Pike, B., & Bohbot, V. D. (2003). Cognitive strategies dependent on the hippocampus and caudate nucleus in human navigation: Variability and change with practice. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 23(13), 5945-5952. 23/13/5945 Link to item
  • Small, D. M., Jones-Gotman, M., & Dagher, A. (2003). Feeding-induced dopamine release in dorsal striatum correlates with meal pleasantness ratings in healthy human volunteers. Neuroimage, 19(4), 1709-1715. S1053811903002532 Link to item
  • Strafella, A. P., Dagher, A., & Sadikot, A. F. (2003). Cerebral blood flow changes induced by subthalamic stimulation in parkinson’s disease. Neurology, 60(6), 1039-1042. Link to item
  • Strafella, A. P., Paus, T., Fraraccio, M., & Dagher, A. (2003). Striatal dopamine release induced by repetitive transcranial magnetic stimulation of the human motor cortex. Brain : A Journal of Neurology, 126(Pt 12), 2609-2615. 10.1093/brain/awg268 Link to item
  • Strafella, A. P., Sadikot, A. F., & Dagher, A. (2003). Subthalamic deep brain stimulation does not induce striatal dopamine release in parkinson’s disease. Neuroreport, 14(9), 1287-1289. 10.1097/01.wnr.0000081873.45938.56 Link to item
  • Leyton, M., Boileau, I., Benkelfat, C., Diksic, M., Baker, G., & Dagher, A. (2002). Amphetamine-induced increases in extracellular dopamine, drug wanting, and novelty seeking: A PET/[11C]raclopride study in healthy men. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 27(6), 1027-1035. S0893133X02003664 Link to item
  • Mendez, I., Dagher, A., Hong, M., Gaudet, P., Weerasinghe, S., McAlister, V., . . . Robertson, H. (2002). Simultaneous intrastriatal and intranigral fetal dopaminergic grafts in patients with parkinson disease: A pilot study. report of three cases. Journal of Neurosurgery, 96(3), 589-596. 10.3171/jns.2002.96.3.0589 Link to item

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